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dc.contributor.author
Lezcano, Virginia Alicia
dc.contributor.author
Mariani, Florencia
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Fernández, Carolina
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Parodi, Elisa Rosalia
dc.contributor.author
Morelli, Susana Ana
dc.date.available
2023-11-10T11:21:54Z
dc.date.issued
2023-02-09
dc.identifier.citation
Lezcano, Virginia Alicia; Mariani, Florencia; Fernández, Carolina; Parodi, Elisa Rosalia; Morelli, Susana Ana; Dictyota dichotoma (phaeophyceae) methanolic extracts exhibit antitumoral effects on breast cancer cells and induce osteoblasts differentiation; Anatolia Academy of sciences; Journal of Applied Biological Sciences; 17; 2; 9-2-2023; 221-234
dc.identifier.uri
http://hdl.handle.net/11336/217688
dc.description.abstract
There is a growing interest in macroalgae as natural products with antioxidant and anticancer activity. In this work, we studied the anti-tumoral effect of an algal extract (AE) derived from the marine alga Dictyota dichotoma on human breast cancer cells (MCF-7). We also evaluated the cytotoxic effects on non-tumorigenic cells and the effects on ostoblastogenesis in vitro. We found that the AE contains high levels of polyphenols and anti-oxidant activity measured by DPPH and Folin-Ciocalteu methods, respectively. Using trypan blue and MTS assays we demonstrated a significant inhibition of MCF-7 cell proliferation and viability. The changes in protein phosphorylation levels were examined through Western blot analysis, finding a decrease of phosphorylated AKT (Ser473) and its target molecule BAD (Ser136). In addition, AE inhibits cell migration determined through the wound healing assay and decreases cellular adhesion at all concentrations probed. Interestingly, AE does not affect the number and morphology of normal osteoblastic human cells, indicating its selectivity. Moreover, using colorimetric methods, we found that low doses of AE increase the production of osteoblastogenesis markers. These findings indicate that D. dichotoma is a valuable source of bioactive compounds for its regulatory effects on processes involved in metastasis and healthy effects in osteoblasts.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Anatolia Academy of sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CYTOTOXICITY
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CELL MIGRATION
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CELL ADHESION
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ALGAL EXTRACT
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OSTEOBLASTOGENESIS
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Dictyota dichotoma (phaeophyceae) methanolic extracts exhibit antitumoral effects on breast cancer cells and induce osteoblasts differentiation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-11-02T14:04:58Z
dc.identifier.eissn
2146-0108
dc.journal.volume
17
dc.journal.number
2
dc.journal.pagination
221-234
dc.journal.pais
Turquía
dc.journal.ciudad
Konya
dc.description.fil
Fil: Lezcano, Virginia Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
dc.description.fil
Fil: Mariani, Florencia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina
dc.description.fil
Fil: Fernández, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Parodi, Elisa Rosalia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina
dc.description.fil
Fil: Morelli, Susana Ana. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Química Biológica; Argentina
dc.journal.title
Journal of Applied Biological Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jabsonline.org/index.php/jabs/article/view/972
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5281/zenodo.8018830
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