Mostrar el registro sencillo del ítem
dc.contributor.author
Chahla, Rossana
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Medina Ruiz, Luis Antonio
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Ferre Contreras, Miguel Enrique
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Raya, Mario
dc.contributor.author
Herrera, Natalia
dc.contributor.author
Ortega, Eugenia Silvana
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Goroso, Daniel Gustavo
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Peral, Maria de Los Angeles
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2023-11-09T13:23:49Z
dc.date.issued
2022-06
dc.identifier.citation
Chahla, Rossana; Medina Ruiz, Luis Antonio; Ferre Contreras, Miguel Enrique; Raya, Mario; Herrera, Natalia; et al.; Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina; OMICS International; Journal of Infectious Diseases & Therapy; 10; S3; 6-2022; 1-5
dc.identifier.uri
http://hdl.handle.net/11336/217647
dc.description.abstract
Purpose: The objective of this work is to make an observational study of the usage in moderate or severe state COVID-19 patients of a new therapeutic commercial product obtained after immunization of horses: CoviFab® ELEA F(ab´)2 fragmented equine immunoglobulins anti SARS-CoV2. Methods: Participant centers depend on the Public Health System of Tucumán, Argentina were recruitment. Subjects were assigned to the Moderate Patient Group (MPG) and the Severe Patient Group (SPG), classified according to WHO criteria. In total, n=84 were enrolled for this study. The subjects were divided into MPG and SPG. All participants were evaluated by physical examination and COVID-19 infection was diagnosed with positive RT-PCR. Each subject received two doses of 0.16 ml/kg, according to the subject´s body weight. A generalized linear model with binomial distribution was adjusted for the number of symptoms. Data was analysed using proportion, bivariate and logistic regression. P-value was consideredsignificant at the p<0.05 threshold. Results: Both groups were similar in age, sex, and comorbidities. A higher proportion of patient with medical discharge was observed in MPG (91.4%) vs. SPG (55.3%) (p=0.004). MPG showed 9 times more chance of receiving medical discharge than SPG (9.33 CI=[1.65, 52.81]; p=0.012). Then, the chance to get medical discharge was independent of variables sex,age, and comorbidities. Conclusion: Treatment with Equine Serum in patients with moderate and severe disease of COVID-19 managed to slightly reduce hospitalization time. This treatment improved the clinical state to obtain medical discharge. The bivariate analysis showed 8 times more chance in MGP versus SGP to receive of medical discharge and this chance was independentof the pre-existent comorbidities.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
OMICS International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
EQUINE SERUM
dc.subject
COVID-19
dc.subject
MODERATE
dc.subject
SEVERE PATIENT
dc.subject.classification
Sistema Respiratorio
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Clínica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-11-01T11:18:09Z
dc.identifier.eissn
2332-0877
dc.journal.volume
10
dc.journal.number
S3
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Chahla, Rossana. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
dc.description.fil
Fil: Medina Ruiz, Luis Antonio. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
dc.description.fil
Fil: Ferre Contreras, Miguel Enrique. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
dc.description.fil
Fil: Raya, Mario. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
dc.description.fil
Fil: Herrera, Natalia. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
dc.description.fil
Fil: Ortega, Eugenia Silvana. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
dc.description.fil
Fil: Goroso, Daniel Gustavo. Mogi das Cruzes University; Brasil
dc.description.fil
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
dc.journal.title
Journal of Infectious Diseases & Therapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/observational-study-application-of-therapy-with-equine-serum-for-patients-diagnosed-with-covid19-in-tucumaacuten-argentina-119547.html
Archivos asociados