Artículo
Antiproliferative activity of withanolide derivatives from Jaborosa cabrerae and Jaborosa reflexa. Chemotaxonomic considerations
García, Manuela Emila
; Barboza, Gloria Estela
; Oberti, Juan Carlos María
; Ríos Luci, Carla; Padrón, José M.; Nicotra, Viviana Estela
; Estevez Braun, Ana; Gutierrez Ravelo, Ángel
Fecha de publicación:
04/2012
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Phytochemistry
ISSN:
0031-9422
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Three withanolides were isolated from the aerial parts of Jaborosa reflexa Phil. Jaborosa cabrerae Barboza yielded five sativolide withanolides (including jaborosalactones R, S, 38, and 39) and two trechonolide withanolides epimeric at C-23 (trechonolide A and jaborosalactone 32). In addition, five derivatives were obtained by chemical derivatization of jaborosalactone 38, and all compounds were fully characterized by 1D and 2D NMR spectroscopic studies. The in vitro antiproliferative activities of the major natural withanolides and the semisynthetic derivatives were examined against HBL-100, HeLa, SW1573, T-47D, and WiDr human solid tumor cancer cell lines. Some chemotaxonomic considerations are discussed.
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Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
García, Manuela Emila; Barboza, Gloria Estela; Oberti, Juan Carlos María; Ríos Luci, Carla; Padrón, José M.; et al.; Antiproliferative activity of withanolide derivatives from Jaborosa cabrerae and Jaborosa reflexa. Chemotaxonomic considerations; Pergamon-Elsevier Science Ltd; Phytochemistry; 76; 4-2012; 150-157
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