Artículo
A Dual-Hormone Multicontroller for Artificial Pancreas Systems
Fecha de publicación:
09/2022
Editorial:
Institute of Electrical and Electronics Engineers
Revista:
IEEE Journal of Biomedical and Health Informatics
ISSN:
2168-2194
e-ISSN:
2168-2208
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Artificial pancreas (AP) algorithms can be divided into single-hormone (SH) and dual-hormone (DH). SH algorithms regulate glycemia using insulin as their control input. On the other hand, DH algorithms also use glucagon to counteract insulin. While SH-AP systems are already commercially available, DH-AP systems are still in an earlier research phase. DH-AP systems have been questioned since the added complexity of glucagon infusion does not always guarantee hypoglycemia prevention and might significantly raise insulin delivery. In this work, a DH multicontroller is proposed based on a SH linear quadratic gaussian (LQG) algorithm with an additional LQG controller to deliver glucagon. This strategy has a switched structure that allows activating one of the following three controllers when necessary: a conservative insulin LQG controller to modulate basal delivery (K1), an aggressive insulin LQG controller to counteract meals (K2), or a glucagon LQG controller to avoid imminent hypoglycemia (K3). Here, an in silico study of the benefits of incorporating controller K3 is carried out. Intra-patient variability and mixed meals are considered. Results indicate that the proposed switched, dual-hormone strategy yields to a reduction in hypoglycemia without increasing hyperglycemia, with no significant rise in insulin delivery.
Palabras clave:
ARTIFICIAL PANCREAS
,
DUAL-HORMONE CONTROL
,
HYPOGLYCEMIA
,
SWITCHED CONTROL
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Colecciones
Articulos(LEICI)
Articulos de INSTITUTO DE INVESTIGACIONES EN ELECTRONICA, CONTROL Y PROCESAMIENTO DE SEÑALES
Articulos de INSTITUTO DE INVESTIGACIONES EN ELECTRONICA, CONTROL Y PROCESAMIENTO DE SEÑALES
Citación
Fushimi, Emilia; de Battista, Hernán; Garelli, Fabricio; A Dual-Hormone Multicontroller for Artificial Pancreas Systems; Institute of Electrical and Electronics Engineers; IEEE Journal of Biomedical and Health Informatics; 26; 9; 9-2022; 4743-4750
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