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dc.contributor.author
Kelly, Maury
dc.contributor.author
Martín, María Julia
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Figueroa, Verónica
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Yogui, Analía
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Gentili, Claudia Rosana
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Brunetto, Oscar
dc.date.available
2023-11-03T13:43:45Z
dc.date.issued
2019
dc.identifier.citation
Hypercalcemia and parathyroid hormone-related peptide expression in a 3 months old boy with Colon Hemangioendothelioma; 9th International Conference on Children´s Bone Health; Salzburg; Austria; 2019; 1-1
dc.identifier.issn
2052-1219
dc.identifier.uri
http://hdl.handle.net/11336/216933
dc.description.abstract
Epithelioid hemangioendothelioma (HEE) is a tumor of vascular origin, infrequent in the pediatric age and even more infrequent at intestinal level. To our knowledge, there are no previous reports of pediatric patients with malignant humoral hypercalcemia associated with this tumor. Humoral mechanism is seen more often in lung, uterine cérvix, skin and esophagus tumors. The presence of hypercalcemia appears to be an ominous prognostic sign.Objective: To report the first case of a patient with hypercalcemia related to PTH-rP associated with Colon HEE in a pediatric patient.Case description: A 3 months years old boy was admited because of clinical worsening and palpable abdominal mass. Initial laboratory investigation revealed hypercalcemia with the following workup: PTH: 1.65 pg/ml, calcium: 25.1 mg/dl, phosphorus 2.9 mg/dl 25ohvitamine D: 25.2 ng/ml, Urine catecholamines were normal. Ultrasound visualized a highly vascularized tumor with calcifications in retroperitoneum of 8×6×6 cm located between liver and right kidney. Biphosphonates and Calcitonin were iniciated without improvement. Biopsy reported epithelioid hemangioendothelioma and angiography revealed tumor irrigated by the middle colic artery. Selective embolization was performed with spongostan and 24 hours later, tumor exeresis was achieved. PTHrP mRNA was identified in the tumor. After surgery the patient attained normocalcemic state, PTH levels normalized and remained normocalcemic to date, 18 months later.Conclusion: We report the first case of PTH-rp related hypercalcemia, with mesocolon epithelioid hemangioendothelioma a pediatric patient. PTH-rp mRNA was detected at tumor level, and the patient resolved hypercalcemia with tumor resection, remaining normocalcemic and with normal PTH levels since then. Selective embolization was important in order to facilitate tumor resection successfully, and improving morbidity and mortality of this surgery.Disclosure: The authors declared no competing interests.
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application/pdf
dc.language.iso
eng
dc.publisher
Biocientifica
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HYPERCALCEMIA
dc.subject
PARATHYROID HORMONE
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PEDIATRIC PATIENT
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COLON HEMANGIOENDOTHELIOMA
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Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Hypercalcemia and parathyroid hormone-related peptide expression in a 3 months old boy with Colon Hemangioendothelioma
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2023-03-28T14:55:10Z
dc.journal.volume
7
dc.journal.pagination
1-1
dc.journal.pais
Austria
dc.journal.ciudad
Salzburg
dc.description.fil
Fil: Kelly, Maury. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
dc.description.fil
Fil: Martín, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
dc.description.fil
Fil: Figueroa, Verónica. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
dc.description.fil
Fil: Yogui, Analía. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
dc.description.fil
Fil: Gentili, Claudia Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
dc.description.fil
Fil: Brunetto, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/www.bone-abstracts.org
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info:eu-repo/semantics/altIdentifier/url/https://www.bone-abstracts.org/ba/0007/ba0007p218
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1530/boneabs.7.P218
dc.conicet.rol
Autor
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Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
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Autor
dc.coverage
Internacional
dc.type.subtype
Congreso
dc.description.nombreEvento
9th International Conference on Children´s Bone Health
dc.date.evento
2019-06-22
dc.description.ciudadEvento
Salzburg
dc.description.paisEvento
Austria
dc.type.publicacion
Journal
dc.description.institucionOrganizadora
9th International Conference on Children´s Bone Health
dc.source.revista
Bone
dc.date.eventoHasta
2019-06-25
dc.type
Congreso
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