Artículo
Oxytocin-Cholinergic Central Interaction: Implications for Non-Social Memory Formation
Medina, Candela
; Krawczyk, Maria del Carmen
; Millan, J.; Blake, Mariano Guillermo
; Boccia, Mariano Martín
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Fecha de publicación:
08/2022
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Neuroscience
ISSN:
0306-4522
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Oxytocin (OT) and vasopressin (AVP) are two closely related neuropeptides implicated in learning and memory processes, anxiety, nociception, addiction, feeding behavior and social information processing. Regarding learning and memory, OT has induced long-lasting impairment in different behaviors, while the opposite was observed with AVP. We have previously evaluated the effect of peripheral administration of OT or its antagonist (AOT) on the inhibitory avoidance response of mice and on the modulation of cholinergic mechanisms. Here, we replicate and validate those results, but this time through central administration of neuropeptides, considering their poor passage through the blood–brain barrier (BBB). When we delivered OT (0.10 ng/mouse) and its antagonist (0.10 ng/mouse) through intracerebroventricular (ICV) injections, the neuropeptide impaired and AOT enhanced the behavioral performance on an inhibitory avoidance response evaluated 48 h after training in a dose-dependent manner. On top of that, we investigated a possible central interaction between OT and the cholinergic system. Administration of anticholinesterases inhibitors with access to the central nervous system (CNS), the activation of muscarinic acetylcholine (Ach) receptors and the increase of evoked ACh release using linopirdine (Lino) (3–10 µg/kg, IP), reversed the impairment of retention performance induced by OT. Besides, either muscarinic or nicotinic antagonists with unrestricted access to the CNS reduced the magnitude of the performance-facilitating effect of AOT's central infusion. We suggest that OT might induce a cholinergic hypofunction state, resulting in an impairment of IA memory formation, a process for which the cholinergic system is crucially necessary.
Palabras clave:
ACETYLCHOLINE
,
INHIBITORY AVOIDANCE
,
LINOPIRDINE
,
MICE
,
NEUROPEPTIDE
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Identificadores
Colecciones
Articulos(IFIBIO HOUSSAY)
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Medina, Candela; Krawczyk, Maria del Carmen; Millan, J.; Blake, Mariano Guillermo; Boccia, Mariano Martín; Oxytocin-Cholinergic Central Interaction: Implications for Non-Social Memory Formation; Pergamon-Elsevier Science Ltd; Neuroscience; 497; 8-2022; 73-85
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