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dc.contributor.author
Kassahun, Getnet S.
dc.contributor.author
Farias, Eliana Desiree
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dc.contributor.author
Benizri, Sebastien
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Mortier, Claudio
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Gaubert, Alexandra
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Salinas, Gerardo
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Garrigue, Patrick
dc.contributor.author
Kuhn, Alexander
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Zigah, Dodzi
dc.contributor.author
Barthélémy, Philippe
dc.date.available
2023-11-01T10:57:52Z
dc.date.issued
2022-06
dc.identifier.citation
Kassahun, Getnet S.; Farias, Eliana Desiree; Benizri, Sebastien; Mortier, Claudio; Gaubert, Alexandra; et al.; Electropolymerizable Thiophene-Oligonucleotides for Electrode Functionalization; American Chemical Society; ACS Applied Materials & Interfaces; 14; 23; 6-2022; 26350-26358
dc.identifier.issn
1944-8244
dc.identifier.uri
http://hdl.handle.net/11336/216717
dc.description.abstract
Inserting complex biomolecules such as oligonucleotides during the synthesis of polymers remains an important challenge in the development of functionalized materials. In order to engineer such a biofunctionalized interface, a single-step method for the covalent immobilization of oligonucleotides (ONs) based on novel electropolymerizable lipid thiophene-oligonucleotide (L-ThON) conjugates was employed. Here, we report a new thiophene phosphoramidite building block for the synthesis of modified L-ThONs. The biofunctionalized material was obtained by direct electropolymerization of L-ThONs in the presence of 2,2′-bithiophene (BTh) to obtain a copolymer film on indium tin oxide electrodes. In situ electroconductance measurements and microstructural studies showed that the L-ThON was incorporated in the BTh copolymer backbone. Furthermore, the covalently immobilized L-ThON sequence showed selectivity in subsequent hybridization processes with a complementary target, demonstrating that L-ThONs can directly be used for manufacturing materials via an electropolymerization strategy. These results indicate that L-ThONs are promising candidates for the development of stable ON-based bioelectrochemical platforms.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIOELECTRODE
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CONDUCTIVE POLYMER
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COVALENT IMMOBILIZATION
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DNA
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ELECTROPOLYMERIZATION
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OLIGONUCLEOTIDE
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THIOPHENE PHOSPHORAMIDITE
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Electropolymerizable Thiophene-Oligonucleotides for Electrode Functionalization
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-31T17:49:55Z
dc.journal.volume
14
dc.journal.number
23
dc.journal.pagination
26350-26358
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington
dc.description.fil
Fil: Kassahun, Getnet S.. Universite de Bordeaux; Francia
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Fil: Farias, Eliana Desiree. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Benizri, Sebastien. Universite de Bordeaux; Francia
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Fil: Mortier, Claudio. Universite de Bordeaux; Francia
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Fil: Gaubert, Alexandra. Universite de Bordeaux; Francia
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Fil: Salinas, Gerardo. Universite de Bordeaux; Francia
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Fil: Garrigue, Patrick. Cnrs, Bordeaux Inp, Ism Umr 5255, Site Enscbp, Pessac; Francia
dc.description.fil
Fil: Kuhn, Alexander. Universite de Bordeaux; Francia
dc.description.fil
Fil: Zigah, Dodzi. Université de Poitiers; Francia. Universite de Bordeaux; Francia
dc.description.fil
Fil: Barthélémy, Philippe. Universite de Bordeaux; Francia
dc.journal.title
ACS Applied Materials & Interfaces
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.2c02993
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acsami.2c02993
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