Transition Metal-Catalyzed Reactions and Solid-Phase Synthesis: A Convenient Blend

Abstract

Transition metal-catalyzed, C−C and C−N bond-forming reactions have made an enormous impact in the way complex molecules are assembled. The benefits of solid-phase chemistry soon made this type of reaction applicable to solid-supported processes. In this review, we report the most recent applications and possibilities of this combination. Remarkably, the solid-phase CuAAC and ring-closing metathesis have demonstrated an important role in synthetic biology, alike more traditional Pd-catalyzed reactions, such as Suzuki-Miyaura, Heck, Sonogashira, which are valuable tools for accessing libraries of biologically relevant small molecules. Examples proved the validity of solid-phase transition metal-catalyzed reactions as a practical and fast strategy to cover the current organic chemistry demands.