Artículo
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin
Russo, Ashley J.; Vasudevan, Swathy O.; Mendez Huergo, Santiago Patricio
; Kumari, Puja; Menoret, Antoine; Duduskar, Shivalee; Wang, Chengliang; Pérez Sáez, Juan Manuel
; Fettis, Margaret M.; Li, Chuan; Liu, Renjie; Wanchoo, Arun; Chandiran, Karthik; Ruan, Jianbin; Vanaja, Sivapriya Kailasan; Bauer, Michael; Sponholz, Christoph; Hudalla, Gregory A.; Vella, Anthony T.; Zhou, Beiyan; Deshmukh, Sachin D.; Rabinovich, Gabriel Adrián
; Rathinam, Vijay A.
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Fecha de publicación:
02/2021
Editorial:
Nature Publishing Group
Revista:
Nature Immunology (print)
ISSN:
1529-2908
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and the concurrent release of damage-associated molecular patterns (DAMPs). Collectively, DAMPs are key determinants that shape the aftermath of inflammatory cell death. However, the identity and function of the individual DAMPs released are poorly defined. Our proteomics study revealed that cytosolic LPS sensing triggered the release of galectin-1, a β-galactoside-binding lectin. Galectin-1 release is a common feature of inflammatory cell death, including necroptosis. In vivo studies using galectin-1-deficient mice, recombinant galectin-1 and galectin-1-neutralizing antibody showed that galectin-1 promotes inflammation and plays a detrimental role in LPS-induced lethality. Mechanistically, galectin-1 inhibition of CD45 (Ptprc) underlies its unfavorable role in endotoxin shock. Finally, we found increased galectin-1 in sera from human patients with sepsis. Overall, we uncovered galectin-1 as a bona fide DAMP released as a consequence of cytosolic LPS sensing, identifying a new outcome of inflammatory cell death.
Palabras clave:
GASDERMIN-D
,
GALECTIN-1
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Russo, Ashley J.; Vasudevan, Swathy O.; Mendez Huergo, Santiago Patricio; Kumari, Puja; Menoret, Antoine; et al.; Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin; Nature Publishing Group; Nature Immunology (print); 22; 2; 2-2021; 154-165
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