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dc.contributor.author
Santibáñez López, Carlos E.
dc.contributor.author
Aharon, Shlomi
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Ballesteros, Jesús A.
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Gainett, Guilherme
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Baker, Caitlin M.
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González Santillán, Edmundo
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Harvey, Mark S.
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Hassan, Mohamed K.
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Abu Almaaty, Ali Hussein
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Aldeyarbi, Shorouk Mohamed
dc.contributor.author
Monod, Lionel
dc.contributor.author
Ojanguren Affilastro, Andres Alejandro
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Pinto-Da-Rocha, Ricardo
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Zvik, Yoram
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Gavish Regev, Efrat
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Sharma, Prashant P.
dc.date.available
2023-10-27T16:37:52Z
dc.date.issued
2022-11
dc.identifier.citation
Santibáñez López, Carlos E.; Aharon, Shlomi; Ballesteros, Jesús A.; Gainett, Guilherme; Baker, Caitlin M.; et al.; Phylogenomics of Scorpions Reveal Contemporaneous Diversification of Scorpion Mammalian Predators and Mammal-Active Sodium Channel Toxins; Oxford University Press; Systematic Biology; 71; 6; 11-2022; 1281-1289
dc.identifier.issn
1063-5157
dc.identifier.uri
http://hdl.handle.net/11336/216251
dc.description.abstract
Scorpions constitute a charismatic lineage of arthropods and comprise more than 2500 described species. Found throughout various tropical and temperate habitats, these predatory arachnids have a long evolutionary history, with a fossil record that began in the Silurian. While all scorpions are venomous, the asymmetrically diverse family Buthidae harbors nearly half the diversity of extant scorpions, and all but one of the 58 species that are medically significant to humans. However, the lack of a densely sampled scorpion phylogeny has hindered broader inferences of the diversification dynamics of scorpion toxins. To redress this gap, we assembled a phylogenomic data set of 100 scorpion venom gland transcriptomes and genomes, emphasizing the sampling of highly toxic buthid genera. To infer divergence times of venom gene families, we applied a phylogenomic node dating approach for the species tree in tandem with phylostratigraphic bracketing to estimate the minimum ages of mammal-specific toxins. Our analyses establish a robustly supported phylogeny of scorpions, particularly with regard to relationships between medically significant taxa. Analysis of venom gene families shows that mammal-active sodium channel toxins (NaTx) have independently evolved in five lineages within Buthidae. Temporal windows of mammal-targeting toxin origins are correlated with the basal diversification of major scorpion mammal predators such as shrews, bats, and rodents. These results suggest an evolutionary model of relatively recent diversification of buthid NaTx homologs in response to the diversification of scorpion predators.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Scoripon
dc.subject
Venom
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Contemporaneous Diversification
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Mammals
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Phylogenomics of Scorpions Reveal Contemporaneous Diversification of Scorpion Mammalian Predators and Mammal-Active Sodium Channel Toxins
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-26T15:21:26Z
dc.journal.volume
71
dc.journal.number
6
dc.journal.pagination
1281-1289
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Santibáñez López, Carlos E.. University of Wisconsin; Estados Unidos. Western Connecticut State University; Estados Unidos
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Fil: Aharon, Shlomi. The Hebrew University of Jerusalem; Israel
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Fil: Ballesteros, Jesús A.. University of Wisconsin; Estados Unidos
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Fil: Gainett, Guilherme. University of Wisconsin; Estados Unidos
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Fil: Baker, Caitlin M.. University of Wisconsin; Estados Unidos. Harvard University; Estados Unidos
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Fil: González Santillán, Edmundo. Universidad Nacional Autónoma de México; México
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Fil: Harvey, Mark S.. Western Australian Museum; Australia
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Fil: Hassan, Mohamed K.. Port Said University; Egipto
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Fil: Abu Almaaty, Ali Hussein. Port Said University; Egipto
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Fil: Aldeyarbi, Shorouk Mohamed. Port Said University; Egipto
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Fil: Monod, Lionel. Museíum Dhistoire Naturelle; Suiza
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Fil: Ojanguren Affilastro, Andres Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Departamento de Invertebrados. Area de Entomologia; Argentina
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Fil: Pinto-Da-Rocha, Ricardo. Universidade de Sao Paulo; Brasil
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Fil: Zvik, Yoram. Ben Gurion University of the Negev; Israel
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Fil: Gavish Regev, Efrat. The Hebrew University of Jerusalem; Israel
dc.description.fil
Fil: Sharma, Prashant P.. University of Wisconsin; Estados Unidos
dc.journal.title
Systematic Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1093/sysbio/syac021
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/sysbio/article/71/6/1281/6554541
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