Artículo
Comparative dissolution studies of albendazole oral suspensions for veterinary use
González Vidal, Noelia Luján
; Starkloff, Walter Javier
; Bentancor, Silvia; Castro, Silvina Gabriela
; Suárez, Gonzalo Pablo
; Palma, Santiago Daniel
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Fecha de publicación:
12/2013
Editorial:
Dissolution Technologies, Inc
Revista:
Dissolution Technologies
ISSN:
1521-298X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Helminth infections are a major health problem mainly in developing countries, and the evidence of emerging resistance to all the major antihelminthics has been recognized in the field of animal husbandry. Albendazole (ABZ) is the most effective broad-spectrum antihelminthic agent. The biggest problem with this drug is its low aqueous solubility, which leads to an erratic availability and great intraindividual variation in the levels reached in different tissues. As with other poorly soluble compounds, the dissolution rate is likely to be contingent on the formulation and may lead to differences in performance among different products available in the market. In previous studies, drastic pharmacokinetic differences were observed among ABZ formulations (oral suspensions) in the Uruguayan market. These samples were evaluated in vitro in terms of ABZ content and dissolution profiles, as well as the effect of increasing agitation speeds on the dissolution rate. The in vitro dissolution rate of formulation A was seriously affected by the increase in agitation speed, and in the case of formulation B, it did not fulfill both essential quality requirements (drug content and dissolution profile). Further studies may be carried out to correlate the suspension quality with its therapeutic effectiveness.
Palabras clave:
Dissolution
,
Albendazole
,
Suspension
,
Veterinary
Archivos asociados
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Colecciones
Articulos(CCT - BAHIA BLANCA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - BAHIA BLANCA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - BAHIA BLANCA
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
González Vidal, Noelia Luján; Starkloff, Walter Javier; Bentancor, Silvia; Castro, Silvina Gabriela; Suárez, Gonzalo Pablo; et al.; Comparative dissolution studies of albendazole oral suspensions for veterinary use; Dissolution Technologies, Inc; Dissolution Technologies; 20; 4; 12-2013; 27-30
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