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dc.contributor.author
Casey, Eric
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dc.contributor.author
Avale, Maria Elena
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dc.contributor.author
Kravitz, Alexxai
dc.contributor.author
Rubinstein, Marcelo
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dc.date.available
2023-10-27T11:41:50Z
dc.date.issued
2023-03
dc.identifier.citation
Casey, Eric; Avale, Maria Elena; Kravitz, Alexxai; Rubinstein, Marcelo; Dopaminergic innervation at the central nucleus of the amygdala reveals distinct topographically segregated regions; Springer Heidelberg; Brain Structure & Function; 228; 2; 3-2023; 663-675
dc.identifier.issn
1863-2653
dc.identifier.uri
http://hdl.handle.net/11336/216139
dc.description.abstract
The central nucleus of the amygdala (CeA) is involved in the expression of fear and anxiety disorders. Anatomically, it is divided into medial (CeM), lateral (CeL), and capsular (CeC) divisions. The CeA is densely innervated by dopaminergic projections that originate in the ventral periaqueductal gray/dorsal raphe (vPAG/DR) and the ventral tegmental area (VTA). However, whether dopamine (DA) exerts a homogenous control over the CeA or differentially regulates the various CeA subdivisions is still unknown. Here, we performed a neuroanatomical analysis of the mouse CeA and found that DAergic innervations from the PAG/DR and VTA constitute distinct, non-overlapping, pathways differing also in the relative expression of the dopamine transporter. By quantifying the distribution of DAergic fibers and the origin of DA inputs we identified two distinct regions in the CeL: a frontal region innervated by the VTA and vPAG/DR, a caudal region innervated only by the vPAG/DR, and three distinct regions in the CeC: fronto-dorsal innervated only by the VTA, fronto-ventral with sparse DAergic innervation, and a caudal region with low innervation from the vPAG/DR. In addition, we found that each region displays a distinct pattern of c-Fos activation following the administration of various DAeric drugs such as cocaine, SKF 38,393, quinpirole or haloperidol. In summary, we revealed unique properties of the DAergic pathways innervating the CeA, distinguishing six topographically segregated and functionally distinct regions. This unanticipated level of heterogeneity calls for more precise neuroanatomical specificity in future functional studies of the CeA.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Heidelberg
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMYGDALA
dc.subject
DOPAMINE
dc.subject
NEUROANATOMY
dc.subject
PERIAQUEDUCTAL GRAY
dc.subject
VENTRAL TEGMENTAL AREA
dc.subject.classification
Anatomía y Morfología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Dopaminergic innervation at the central nucleus of the amygdala reveals distinct topographically segregated regions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-25T10:10:14Z
dc.journal.volume
228
dc.journal.number
2
dc.journal.pagination
663-675
dc.journal.pais
Alemania
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dc.description.fil
Fil: Casey, Eric. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Avale, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Kravitz, Alexxai. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.journal.title
Brain Structure & Function
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00429-023-02614-1
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