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dc.contributor.author
Leignel, Vincent
dc.contributor.author
Pillot, Louis
dc.contributor.author
Gerpe, Marcela Silvia
dc.contributor.author
Caurant, Florence
dc.date.available
2023-10-26T17:44:04Z
dc.date.issued
2023-05
dc.identifier.citation
Leignel, Vincent; Pillot, Louis; Gerpe, Marcela Silvia; Caurant, Florence; Assessment of Knowledge on Metal Trace Element Concentrations and Metallothionein Biomarkers in Cetaceans; MDPI; Toxics; 11; 5; 5-2023; 454-467
dc.identifier.issn
2305-6304
dc.identifier.uri
http://hdl.handle.net/11336/216089
dc.description.abstract
Cetaceans are recognized as bioindicators of pollution in oceans. These marine mammals are final trophic chain consumers and easily accumulate pollutants. For example, metals are abundant in oceans and commonly found in the cetacean tissues. Metallothioneins (MTs) are small non-enzyme proteins involved in metal cell regulation and are essential in many cellular processes (cell proliferation, redox balance, etc.). Thus, the MT levels and the concentrations of metals in cetacean tissue are positively correlated. Four types of metallothioneins (MT1, 2, 3, and 4) are found in mammals, which may have a distinct expression in tissues. Surprisingly, only a few genes or mRNA-encoding metallothioneins are characterized in cetaceans; molecular studies are focused on MT quantification, using biochemical methods. Thus, we characterized, in transcriptomic and genomic data, more than 200 complete sequences of metallothioneins (mt1, 2, 3, and 4) in cetacean species to study their structural variability and to propose to the scientific research community Mt genes dataset to develop in future molecular approaches which will study the four types of metallothioneins in diversified organs (brain, gonad, intestine, kidney, stomach, etc.).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CETACEANS
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GENE
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METALLOTHIONEINS
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MRNA
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POLLUTION
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Assessment of Knowledge on Metal Trace Element Concentrations and Metallothionein Biomarkers in Cetaceans
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-25T10:17:26Z
dc.journal.volume
11
dc.journal.number
5
dc.journal.pagination
454-467
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Leignel, Vincent. Le Mans Université.; Francia
dc.description.fil
Fil: Pillot, Louis. Le Mans Université.; Francia
dc.description.fil
Fil: Gerpe, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
dc.description.fil
Fil: Caurant, Florence. La Rochelle University; Francia
dc.journal.title
Toxics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/toxics11050454
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