Artículo
Beneficial effects of metformin on mice female fertility after a high-fat diet intake
Velazquez, Candela
; Herrero, Yamila; Bianchi, Maria Silvia
; Cohen, Debora Juana
; Cuasnicu, Patricia Sara
; Prost, Katherine; Marinoni, Rocío Celeste; Pascuali, Natalia Marisa
; Parborell, Maria Fernanda Agustina
; Abramovich, Dalhia Nurit
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Fecha de publicación:
09/2023
Editorial:
Elsevier Ireland
Revista:
Molecular and Cellular Endocrinology
ISSN:
0303-7207
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Female fertility is highly dependent on energy balance. High fat diet (HFD) intake entails a risk of infertility and ovulatory disorders. Considering the increase in the prevalence of overweight and obesity over the last decades, it is crucial to understand the mechanisms involved in overweight-associated infertility. In this study, we evaluated the reproductive performance of female mice fed with a HFD and the effects of metformin administration on ovarian function in these mice. We hypothesized that one of the mechanisms involved in subfertility due to a HFD intake is the alteration of ovarian blood vessel formation. We found that mice fed with HFD had altered estrous cycles and steroidogenesis, increased ovarian fibrosis, fewer pups per litter and require more time to achieve pregnancy. HFD-fed mice also presented dysregulated ovarian angiogenesis and an increase in nuclear DNA damage in ovarian cells. Ovulation rates were lower in these animals, as evidenced both in natural mating and after ovulation induction with gonadotropins. Metformin ameliorated ovarian angiogenesis, improved steroidogenesis, fibrosis, and ovulation, decreased the time to pregnancy and increased litter sizes in HFD-fed mice. We conclude that ovarian angiogenesis is one of the mechanisms detrimentally affected by HFD intake. Since metformin could improve ovarian microvasculature, it may be an interesting strategy to study in women to shed light on new targets for patients with metabolic disturbances.
Palabras clave:
ANGIOGENESIS
,
FERTILITY
,
HIGH-FAT DIET
,
METFORMIN
,
OVARY
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Velazquez, Candela; Herrero, Yamila; Bianchi, Maria Silvia; Cohen, Debora Juana; Cuasnicu, Patricia Sara; et al.; Beneficial effects of metformin on mice female fertility after a high-fat diet intake; Elsevier Ireland; Molecular and Cellular Endocrinology; 575; 9-2023; 1-44
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