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dc.contributor.author
Singhal, Sandeep K.
dc.contributor.author
Byun, Jung S.
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dc.contributor.author
Yan, Tingfen
dc.contributor.author
Yancey, Ryan
dc.contributor.author
Caban, Ambar
dc.contributor.author
Hernandez, Sara Gil
dc.contributor.author
Bufford, Sediqua
dc.contributor.author
Hewitt, Stephen M.
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dc.contributor.author
Winfield, Joy
dc.contributor.author
Pradhan, Jaya
dc.contributor.author
Mustkov, Vesco
dc.contributor.author
McDonald, Jasmine A.
dc.contributor.author
Pérez Stable, Eliseo J.
dc.contributor.author
Nápoles, Anna María
dc.contributor.author
Vohra, Nasreen
dc.contributor.author
de Siervi, Adriana
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dc.contributor.author
Yates, Clayton
dc.contributor.author
Davis, Melissa B.
dc.contributor.author
Yang, Mei
dc.contributor.author
Tsai, Yien Che
dc.contributor.author
Weissman, Allan M.
dc.contributor.author
Gardner, Kevin
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dc.date.available
2023-10-25T17:38:25Z
dc.date.issued
2022-07
dc.identifier.citation
Singhal, Sandeep K.; Byun, Jung S.; Yan, Tingfen; Yancey, Ryan; Caban, Ambar; et al.; Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race; American Society for Clinical Investigation; JCI Insight; 7; 13; 7-2022; 1-19
dc.identifier.issn
2379-3708
dc.identifier.uri
http://hdl.handle.net/11336/215952
dc.description.abstract
Women of African ancestry suffer higher rates of breast cancer mortality compared with all other groups in the United States. Though the precise reasons for these disparities remain unclear, many recent studies have implicated a role for differences in tumor biology. Using an epitope-validated antibody against the endoplasmic reticulum-associated E3 ligase, gp78, we show that elevated levels of gp78 in patient breast cancer cells predict poor survival. Moreover, high levels of gp78 are associated with poor outcomes in both ER+ and ER- tumors, and breast cancers expressing elevated amounts of gp78 protein are enriched in gene expression pathways that influence cell cycle, metabolism, receptor-mediated signaling, and cell stress response pathways. In multivariate analysis adjusted for subtype and grade, gp78 protein is an independent predictor of poor outcomes in women of African ancestry. Furthermore, gene expression signatures, derived from patients stratified by gp78 protein expression, are strong predictors of recurrence and pathological complete response in retrospective clinical trial data and share many common features with gene sets previously identified to be overrepresented in breast cancers based on race. These findings implicate a prominent role for gp78 in tumor progression and offer insights into our understanding of racial differences in breast cancer outcomes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Clinical Investigation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GP78
dc.subject
BREAST CANCER
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-25T10:05:39Z
dc.journal.volume
7
dc.journal.number
13
dc.journal.pagination
1-19
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Singhal, Sandeep K.. No especifíca;
dc.description.fil
Fil: Byun, Jung S.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Yan, Tingfen. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Yancey, Ryan. Columbia University; Estados Unidos
dc.description.fil
Fil: Caban, Ambar. Columbia University; Estados Unidos
dc.description.fil
Fil: Hernandez, Sara Gil. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Bufford, Sediqua. No especifíca;
dc.description.fil
Fil: Hewitt, Stephen M.. No especifíca;
dc.description.fil
Fil: Winfield, Joy. Columbia University; Estados Unidos
dc.description.fil
Fil: Pradhan, Jaya. Columbia University; Estados Unidos
dc.description.fil
Fil: Mustkov, Vesco. Columbia University; Estados Unidos
dc.description.fil
Fil: McDonald, Jasmine A.. No especifíca;
dc.description.fil
Fil: Pérez Stable, Eliseo J.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Nápoles, Anna María. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Vohra, Nasreen. No especifíca;
dc.description.fil
Fil: de Siervi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Yates, Clayton. No especifíca;
dc.description.fil
Fil: Davis, Melissa B.. No especifíca;
dc.description.fil
Fil: Yang, Mei. No especifíca;
dc.description.fil
Fil: Tsai, Yien Che. No especifíca;
dc.description.fil
Fil: Weissman, Allan M.. No especifíca;
dc.description.fil
Fil: Gardner, Kevin. Columbia University; Estados Unidos
dc.journal.title
JCI Insight
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://insight.jci.org/articles/view/157465
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1172/jci.insight.157465
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