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dc.contributor.author
Akkari, Yassmine M.N.  
dc.contributor.author
Baughn, Linda B.  
dc.contributor.author
Dubuc, Adrian M.  
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Smith, Adam C.  
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Mallo, Mar  
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Dal Cin, Paola  
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Diez Campelo, Maria  
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Gallego, Marta S.  
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Granada Font, Isabel  
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Haase, Detlef T.  
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Schlegelberger, Brigitte  
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Slavutsky, Irma Rosa  
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Mecucci, Cristina  
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Levine, Ross L.  
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Hasserjian, Robert P.  
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Solé, Francesc  
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Levy, Brynn  
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Xu, Xinjie  
dc.date.available
2023-10-25T17:28:02Z  
dc.date.issued
2022-04  
dc.identifier.citation
Akkari, Yassmine M.N.; Baughn, Linda B.; Dubuc, Adrian M.; Smith, Adam C.; Mallo, Mar; et al.; Guiding the global evolution of cytogenetic testing for hematologic malignancies; American Society of Hematology; Blood; 139; 15; 4-2022; 2273-2284  
dc.identifier.issn
0006-4971  
dc.identifier.uri
http://hdl.handle.net/11336/215947  
dc.description.abstract
Cytogenetics has long represented a critical component in the clinical evaluation of hematologic malignancies. Chromosome banding studies provide a simultaneous snapshot of genome-wide copy number and structural variation, which have been shown to drive tumorigenesis, define diseases, and guide treatment. Technological innovations in sequencing have ushered in our present-day clinical genomics era. With recent publications highlighting novel sequencing technologies as alternatives to conventional cytogenetic approaches, we, an international consortium of laboratory geneticists, pathologists, and oncologists, describe herein the advantages and limitations of both conventional chromosome banding and novel sequencing technologies and share our considerations on crucial next steps to implement these novel technologies in the global clinical setting for a more accurate cytogenetic evaluation, which may provide improved diagnosis and treatment management. Considering the clinical, logistic, technical, and financial implications, we provide points to consider for the global evolution of cytogenetic testing.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Society of Hematology  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
CYTOGENETICS  
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G-BANDING  
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Genética Humana  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Guiding the global evolution of cytogenetic testing for hematologic malignancies  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-14T20:22:40Z  
dc.identifier.eissn
1528-0020  
dc.journal.volume
139  
dc.journal.number
15  
dc.journal.pagination
2273-2284  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
New York  
dc.description.fil
Fil: Akkari, Yassmine M.N.. Legacy Health; Estados Unidos  
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Fil: Baughn, Linda B.. Mayo Clinic Cancer Center; Estados Unidos  
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Fil: Dubuc, Adrian M.. Harvard Medical School; Estados Unidos  
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Fil: Smith, Adam C.. University of Toronto; Canadá  
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Fil: Mallo, Mar. Institut D`investigació Biomedica de Girona Dr. Josep Trueta (idib`gi);  
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Fil: Dal Cin, Paola. Harvard Medical School; Estados Unidos  
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Fil: Diez Campelo, Maria. Universidad de Salamanca; España  
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Fil: Gallego, Marta S.. Hospital Italiano; Argentina  
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Fil: Granada Font, Isabel. Institut D`investigació Biomedica de Girona Dr. Josep Trueta (idib`gi);  
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Fil: Haase, Detlef T.. Universität Göttingen; Alemania  
dc.description.fil
Fil: Schlegelberger, Brigitte. Leibniz Universitat Hannover; Alemania  
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Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
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Fil: Mecucci, Cristina. Università di Perugia; Italia  
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Fil: Levine, Ross L.. Memorial Sloan-kettering Cancer Center; Estados Unidos  
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Fil: Hasserjian, Robert P.. Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School;  
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Fil: Solé, Francesc. Institut D`investigació Biomedica de Girona Dr. Josep Trueta (idib`gi);  
dc.description.fil
Fil: Levy, Brynn. Columbia University; Estados Unidos  
dc.description.fil
Fil: Xu, Xinjie. Mayo Clinic Cancer Center; Estados Unidos  
dc.journal.title
Blood  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://ashpublications.org/blood/article/139/15/2273/484041/Guiding-the-global-evolution-of-cytogenetic  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1182/blood.2021014309