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dc.contributor.author
Akkari, Yassmine M.N.
dc.contributor.author
Baughn, Linda B.
dc.contributor.author
Dubuc, Adrian M.
dc.contributor.author
Smith, Adam C.
dc.contributor.author
Mallo, Mar
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Dal Cin, Paola
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Diez Campelo, Maria
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Gallego, Marta S.
dc.contributor.author
Granada Font, Isabel
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Haase, Detlef T.
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Schlegelberger, Brigitte
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Slavutsky, Irma Rosa
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Mecucci, Cristina
dc.contributor.author
Levine, Ross L.
dc.contributor.author
Hasserjian, Robert P.
dc.contributor.author
Solé, Francesc
dc.contributor.author
Levy, Brynn
dc.contributor.author
Xu, Xinjie
dc.date.available
2023-10-25T17:28:02Z
dc.date.issued
2022-04
dc.identifier.citation
Akkari, Yassmine M.N.; Baughn, Linda B.; Dubuc, Adrian M.; Smith, Adam C.; Mallo, Mar; et al.; Guiding the global evolution of cytogenetic testing for hematologic malignancies; American Society of Hematology; Blood; 139; 15; 4-2022; 2273-2284
dc.identifier.issn
0006-4971
dc.identifier.uri
http://hdl.handle.net/11336/215947
dc.description.abstract
Cytogenetics has long represented a critical component in the clinical evaluation of hematologic malignancies. Chromosome banding studies provide a simultaneous snapshot of genome-wide copy number and structural variation, which have been shown to drive tumorigenesis, define diseases, and guide treatment. Technological innovations in sequencing have ushered in our present-day clinical genomics era. With recent publications highlighting novel sequencing technologies as alternatives to conventional cytogenetic approaches, we, an international consortium of laboratory geneticists, pathologists, and oncologists, describe herein the advantages and limitations of both conventional chromosome banding and novel sequencing technologies and share our considerations on crucial next steps to implement these novel technologies in the global clinical setting for a more accurate cytogenetic evaluation, which may provide improved diagnosis and treatment management. Considering the clinical, logistic, technical, and financial implications, we provide points to consider for the global evolution of cytogenetic testing.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Hematology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CYTOGENETICS
dc.subject
G-BANDING
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Genética Humana
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Guiding the global evolution of cytogenetic testing for hematologic malignancies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-14T20:22:40Z
dc.identifier.eissn
1528-0020
dc.journal.volume
139
dc.journal.number
15
dc.journal.pagination
2273-2284
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Akkari, Yassmine M.N.. Legacy Health; Estados Unidos
dc.description.fil
Fil: Baughn, Linda B.. Mayo Clinic Cancer Center; Estados Unidos
dc.description.fil
Fil: Dubuc, Adrian M.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Smith, Adam C.. University of Toronto; Canadá
dc.description.fil
Fil: Mallo, Mar. Institut D`investigació Biomedica de Girona Dr. Josep Trueta (idib`gi);
dc.description.fil
Fil: Dal Cin, Paola. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Diez Campelo, Maria. Universidad de Salamanca; España
dc.description.fil
Fil: Gallego, Marta S.. Hospital Italiano; Argentina
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Fil: Granada Font, Isabel. Institut D`investigació Biomedica de Girona Dr. Josep Trueta (idib`gi);
dc.description.fil
Fil: Haase, Detlef T.. Universität Göttingen; Alemania
dc.description.fil
Fil: Schlegelberger, Brigitte. Leibniz Universitat Hannover; Alemania
dc.description.fil
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Mecucci, Cristina. Università di Perugia; Italia
dc.description.fil
Fil: Levine, Ross L.. Memorial Sloan-kettering Cancer Center; Estados Unidos
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Fil: Hasserjian, Robert P.. Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School;
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Fil: Solé, Francesc. Institut D`investigació Biomedica de Girona Dr. Josep Trueta (idib`gi);
dc.description.fil
Fil: Levy, Brynn. Columbia University; Estados Unidos
dc.description.fil
Fil: Xu, Xinjie. Mayo Clinic Cancer Center; Estados Unidos
dc.journal.title
Blood
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://ashpublications.org/blood/article/139/15/2273/484041/Guiding-the-global-evolution-of-cytogenetic
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1182/blood.2021014309
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