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dc.contributor.author
Li, Hao
dc.contributor.author
Namburi, Praneeth
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Olson, Jacob M.
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Borio, Matilde
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Lemieux, Mackenzie E.
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Beyeler, Anna
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Calhoon, Gwendolyn G.
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Hitora Imamura, Natsuko
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Coley, Austin A.
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Libster, Avraham
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Bal, Aneesh
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Jin, Xin
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Wang, Huan
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Jia, Caroline
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Choudhury, Sourav R.
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Shi, Xi
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Felix Ortiz, Ada C.
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de la Fuente, Verónica
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Barth, Vanessa P.
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King, Hunter O.
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Izadmehr, Ehsan M.
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Revanna, Jasmin S.
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Batra, Kanha
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Fischer, Kyle B.
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Keyes, Laurel R.
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Padilla-Coreano, Nancy
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Siciliano, Cody A.
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McCullough, Kenneth M.
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Wichmann, Romy
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Ressler, Kerry J.
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Fiete, Ila R.
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Zhang, Feng
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Li, Yulong
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Tye, Kay M.
dc.date.available
2023-10-24T13:54:03Z
dc.date.issued
2022-08
dc.identifier.citation
Li, Hao; Namburi, Praneeth; Olson, Jacob M.; Borio, Matilde; Lemieux, Mackenzie E.; et al.; Neurotensin orchestrates valence assignment in the amygdala; Nature Publishing Group; Nature; 608; 7923; 8-2022; 586-592
dc.identifier.issn
0028-0836
dc.identifier.uri
http://hdl.handle.net/11336/215734
dc.description.abstract
The ability to associate temporally segregated information and assign positive or negative valence to environmental cues is paramount for survival. Studies have shown that different projections from the basolateral amygdala (BLA) are potentiated following reward or punishment learning1–7. However, we do not yet understand how valence-specific information is routed to the BLA neurons with the appropriate downstream projections, nor do we understand how to reconcile the sub-second timescales of synaptic plasticity8–11 with the longer timescales separating the predictive cues from their outcomes. Here we demonstrate that neurotensin (NT)-expressing neurons in the paraventricular nucleus of the thalamus (PVT) projecting to the BLA (PVT-BLA:NT) mediate valence assignment by exerting NT concentration-dependent modulation in BLA during associative learning. We found that optogenetic activation of the PVT-BLA:NT projection promotes reward learning, whereas PVT-BLA projection-specific knockout of the NT gene (Nts) augments punishment learning. Using genetically encoded calcium and NT sensors, we further revealed that both calcium dynamics within the PVT-BLA:NT projection and NT concentrations in the BLA are enhanced after reward learning and reduced after punishment learning. Finally, we showed that CRISPR-mediated knockout of the Nts gene in the PVT-BLA pathway blunts BLA neural dynamics and attenuates the preference for active behavioural strategies to reward and punishment predictive cues. In sum, we have identified NT as a neuropeptide that signals valence in the BLA, and showed that NT is a critical neuromodulator that orchestrates positive and negative valence assignment in amygdala neurons by extending valence-specific plasticity to behaviourally relevant timescales.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NEUROTENSIN
dc.subject
VALENCE
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AMYGDALA
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Neurotensin orchestrates valence assignment in the amygdala
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-30T10:52:26Z
dc.journal.volume
608
dc.journal.number
7923
dc.journal.pagination
586-592
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Li, Hao. Salk Institute for Biological Studies; Estados Unidos
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Fil: Namburi, Praneeth. Massachusetts Institute of Technology; Estados Unidos
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Fil: Olson, Jacob M.. Massachusetts Institute of Technology; Estados Unidos. Brandeis University; Estados Unidos
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Fil: Borio, Matilde. Salk Institute for Biological Studies; Estados Unidos. Massachusetts Institute of Technology; Estados Unidos
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Fil: Lemieux, Mackenzie E.. Massachusetts Institute of Technology; Estados Unidos. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Beyeler, Anna. Massachusetts Institute of Technology; Estados Unidos. Universite de Bordeaux; Francia
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Fil: Calhoon, Gwendolyn G.. Bates College; Estados Unidos. Massachusetts Institute of Technology; Estados Unidos
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Fil: Hitora Imamura, Natsuko. Hokkaido University; Japón. Kumamoto University; Japón. Massachusetts Institute of Technology; Estados Unidos
dc.description.fil
Fil: Coley, Austin A.. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Libster, Avraham. Salk Institute for Biological Studies; Estados Unidos. Massachusetts Institute of Technology; Estados Unidos
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Fil: Bal, Aneesh. Salk Institute for Biological Studies; Estados Unidos. Michigan State University; Estados Unidos
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Fil: Jin, Xin. Broad Institute; Estados Unidos. Harvard University; Estados Unidos
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Fil: Wang, Huan. Peking University; China
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Fil: Jia, Caroline. University of California at San Diego; Estados Unidos. Salk Institute for Biological Studies; Estados Unidos
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Fil: Choudhury, Sourav R.. Broad Institute; Estados Unidos
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Fil: Shi, Xi. Broad Institute; Estados Unidos. Massachusetts Institute of Technology; Estados Unidos
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Fil: Felix Ortiz, Ada C.. Massachusetts Institute of Technology; Estados Unidos
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Fil: de la Fuente, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Massachusetts Institute of Technology; Estados Unidos. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
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Fil: Barth, Vanessa P.. Massachusetts Institute of Technology; Estados Unidos. Universitat Technical Zu Munich; Alemania
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Fil: King, Hunter O.. Massachusetts Institute of Technology; Estados Unidos
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Fil: Izadmehr, Ehsan M.. Massachusetts Institute of Technology; Estados Unidos
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Fil: Revanna, Jasmin S.. Salk Institute for Biological Studies; Estados Unidos. University of California; Estados Unidos
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Fil: Batra, Kanha. Salk Institute for Biological Studies; Estados Unidos. University of California; Estados Unidos
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Fil: Fischer, Kyle B.. Salk Institute for Biological Studies; Estados Unidos
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Fil: Keyes, Laurel R.. Salk Institute for Biological Studies; Estados Unidos
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Fil: Padilla-Coreano, Nancy. Salk Institute for Biological Studies; Estados Unidos
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Fil: Siciliano, Cody A.. Massachusetts Institute of Technology; Estados Unidos. Vanderbilt University; Estados Unidos
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Fil: McCullough, Kenneth M.. McLean Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
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Fil: Wichmann, Romy. Salk Institute for Biological Studies; Estados Unidos. Massachusetts Institute of Technology; Estados Unidos
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Fil: Ressler, Kerry J.. McLean Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
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Fil: Fiete, Ila R.. Massachusetts Institute of Technology; Estados Unidos
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Fil: Zhang, Feng. Massachusetts Institute of Technology; Estados Unidos. Stanley Center for Psychiatric Research; Estados Unidos. Broad Institute; Estados Unidos
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Fil: Li, Yulong. Peking University School of Life Sciences; China
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Fil: Tye, Kay M.. Massachusetts Institute of Technology; Estados Unidos. Salk Institute for Biological Studies; Estados Unidos
dc.journal.title
Nature
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41586-022-04964-y
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41586-022-04964-y
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