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dc.contributor.author
Ash, Ryan T.
dc.contributor.author
Palagina, Ganna
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Fernandez Leon, Jose Alberto
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Park, Jiyoung
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Seilheimer, Rob
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Lee, Sangkyun
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Sabharwal, Jasdeep
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Reyes, Fredy
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Wang, Jing
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Lu, Dylan
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Sarfraz, Muhammad
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Froudarakis, Emmanouil
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Tolias, Andreas S.
dc.contributor.author
Wu, Samuel M.
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Smirnakis, Stelios M.
dc.date.available
2023-10-23T14:00:04Z
dc.date.issued
2022-08
dc.identifier.citation
Ash, Ryan T.; Palagina, Ganna; Fernandez Leon, Jose Alberto; Park, Jiyoung; Seilheimer, Rob; et al.; Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism; Society for Neuroscience; Journal of Neuroscience; 42; 33; 8-2022; 6469-6482
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/215639
dc.description.abstract
Atypical sensory processing is now thought to be a core feature of the autism spectrum. Influential theories have proposed that both increased and decreased neural response reliability within sensory systems could underlie altered sensory processing in autism. Here, we report evidence for abnormally increased reliability of visual-evoked responses in layer 2/3 neurons of adult male and female primary visual cortex in the MECP2-duplication syndrome animal model of autism. Increased response reliability was due in part to decreased response amplitude, decreased fluctuations in endogenous activity, and an abnormal decoupling of visual-evoked activity from endogenous activity. Similar to what was observed neuronally, the optokinetic reflex occurred more reliably at low contrasts in mutant mice compared with controls. Retinal responses did not explain our observations. These data suggest that the circuit mechanisms for combining sensory-evoked and endogenous signal and noise processes may be altered in this form of syndromic autism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ASD
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AUTISM
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CALCIUM IMAGING
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MECP2
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MOUSE
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VISUAL CORTEX
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Ciencias de la Información y Bioinformática
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Ciencias de la Computación e Información
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T21:58:07Z
dc.journal.volume
42
dc.journal.number
33
dc.journal.pagination
6469-6482
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Ash, Ryan T.. Baylor College of Medicine; Estados Unidos. Harvard Medical School; Estados Unidos. University of Stanford; Estados Unidos
dc.description.fil
Fil: Palagina, Ganna. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Fernandez Leon, Jose Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Park, Jiyoung. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos
dc.description.fil
Fil: Seilheimer, Rob. University of Pennsylvania; Estados Unidos. Baylor College of Medicine; Estados Unidos
dc.description.fil
Fil: Lee, Sangkyun. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Sabharwal, Jasdeep. Baylor College of Medicine; Estados Unidos. University Johns Hopkins; Estados Unidos
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Fil: Reyes, Fredy. Baylor College of Medicine; Estados Unidos
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Fil: Wang, Jing. Baylor College of Medicine; Estados Unidos
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Fil: Lu, Dylan. Harvard Medical School; Estados Unidos
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Fil: Sarfraz, Muhammad. Harvard Medical School; Estados Unidos
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Fil: Froudarakis, Emmanouil. Baylor College of Medicine; Estados Unidos. Foundation For Research And Technology; Grecia
dc.description.fil
Fil: Tolias, Andreas S.. Baylor College of Medicine; Estados Unidos
dc.description.fil
Fil: Wu, Samuel M.. Baylor College of Medicine; Estados Unidos
dc.description.fil
Fil: Smirnakis, Stelios M.. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.0654-22.2022
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/42/33/6469
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