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dc.contributor.author
Akseer, Nadia
dc.contributor.author
Keats, Emily Catherine
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Thurairajah, Pravheen
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Cousens, Simon
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Bétran, Ana Pilar
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Oaks, Brietta M.
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Osrin, David
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Piwoz, Ellen
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Gomo, Exnevia
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Ahmed, Faruk
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Friis, Henrik
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Belizan, Jose
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Dewey, Kathryn
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West, Keith
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Huybregts, Lieven
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Zeng, Lingxia
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Dibley, Michael J.
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Zagre, Noel
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Christian, Parul
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Kolsteren, Patrick Wilfried
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Kaestel, Pernille
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Black, Robert E.
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El Arifeen, Shams
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Ashorn, Ulla
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Fawzi, Wafaie
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Bhutta, Zulfiqar Ahmed
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The Global Young Women's Nutrition Investigators Group
dc.date.available
2023-10-20T19:03:28Z
dc.date.issued
2022-03
dc.identifier.citation
Akseer, Nadia; Keats, Emily Catherine; Thurairajah, Pravheen; Cousens, Simon; Bétran, Ana Pilar; et al.; Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs; Elsevier; eClinicalMedicine; 45; 101309; 3-2022; 1-14
dc.identifier.issn
2589-5370
dc.identifier.uri
http://hdl.handle.net/11336/215618
dc.description.abstract
Background: Adolescence is a critical period of maturation when nutrient needs are high, especially among adolescents entering pregnancy. Using individual-level data from 140,000 participants, we examined socioeconomic, nutrition, and pregnancy and birth outcomes for adolescent mothers (10–19 years) compared to older mothers in low and middle-income countries. Methods: This study was conducted between March 16, 2018 and May 25, 2021. Data were obtained from 20 randomised controlled trials of micronutrient supplementation in pregnancy. Stratified analyses were conducted by age (10–14 years, 15–17 years, 18–19 years, 20–29 years, 30–39 years, 40+ years) and geographical region (Africa, Asia). Crude and confounder-adjusted means, prevalence and relative risks of pregnancy, nutrition and birth outcomes were estimated using multivariable linear and log-binomial regression models with 95% confidence intervals. Findings: Adolescent mothers comprised 31.6% of our data. Preterm birth, small-for-gestational age (SGA), low birthweight (LBW) and newborn mortality followed a U-shaped trend in which prevalence was highest among the youngest mothers (10–14 years) and then reduced gradually, but increased again for older mothers (40+ years). When compared to mothers aged 20–29 years, there was a 23% increased risk of preterm birth, a 60% increased risk of perinatal mortality, a 63% increased risk of neonatal mortality, a 28% increased risk of LBW, and a 22% increased risk of SGA among mothers 10–14 years. Mothers 40+ years experienced a 22% increased risk of preterm birth and a 103% increased risk of stillbirth when compared to the 20–29 year group. Interpretation: The youngest and oldest mothers suffer most from adverse pregnancy and birth outcomes. Policy and programming agendas should consider both biological and socioeconomic/environmental factors when targeting these populations. Funding: Bill and Melinda Gates Foundation (Grant No: OP1137750).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ADOLESCENCE
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AGE
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BIRTH OUTCOMES
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DETERMINANTS
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PREGNANCY
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Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-10T11:58:30Z
dc.journal.volume
45
dc.journal.number
101309
dc.journal.pagination
1-14
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Berlín
dc.description.fil
Fil: Akseer, Nadia. University of Toronto. Hospital for Sick Children. División of Clinical Pharmacology & Toxicology; Canadá
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Fil: Keats, Emily Catherine. University of Toronto. Hospital for Sick Children. División of Clinical Pharmacology & Toxicology; Canadá
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Fil: Thurairajah, Pravheen. University Of Toronto. Hospital For Sick Children; Canadá
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Fil: Cousens, Simon. London School Of Hygiene And Tropical Medicine; Reino Unido
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Fil: Bétran, Ana Pilar. Organizacion Mundial de la Salud; Argentina
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Fil: Oaks, Brietta M.. University of Rhode Island; Estados Unidos
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Fil: Osrin, David. Institute For Global Health; Reino Unido
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Fil: Piwoz, Ellen. The Bill And Melinda Gates Foundation; Estados Unidos
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Fil: Gomo, Exnevia. University Of Zimbabwe; Zimbabue
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Fil: Ahmed, Faruk. Griffith University; Australia
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Fil: Friis, Henrik. University Of Copenhagen. Faculty Of Health And Medical Sciences.; Dinamarca
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Fil: Belizan, Jose. University of North Carolina; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
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Fil: Dewey, Kathryn. University of California; Estados Unidos
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Fil: West, Keith. University Johns Hopkins; Estados Unidos
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Fil: Huybregts, Lieven. International Food Policy Research Institute; Estados Unidos
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Fil: Zeng, Lingxia. Xi'an Jiaotong University Health Science Centre; China
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Fil: Dibley, Michael J.. The University Of Sydney; Australia
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Fil: Zagre, Noel. Organización de Las Naciones Unidas; Argentina
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Fil: Christian, Parul. University Johns Hopkins; Estados Unidos
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Fil: Kolsteren, Patrick Wilfried. Ghent University; Bélgica
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Fil: Kaestel, Pernille. University Of Copenhagen. Faculty Of Health And Medical Sciences.; Dinamarca
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Fil: Black, Robert E.. University Johns Hopkins; Estados Unidos
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Fil: El Arifeen, Shams. Icddrb; Bangladesh
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Fil: Ashorn, Ulla. Universidad de Tampere; Finlandia
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Fil: Fawzi, Wafaie. Harvard T.h. Chan School Of Public Health; Estados Unidos
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Fil: Bhutta, Zulfiqar Ahmed. University Of Toronto. Hospital For Sick Children; Canadá
dc.description.fil
Fil: The Global Young Women's Nutrition Investigators Group. No especifíca;
dc.journal.title
eClinicalMedicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2589537022000396
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.eclinm.2022.101309
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