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dc.contributor.author
Krause, Laura J.
dc.contributor.author
Herrera, Maria Georgina
dc.contributor.author
Winklhofer, Konstanze F.
dc.date.available
2023-10-20T14:26:55Z
dc.date.issued
2022-05
dc.identifier.citation
Krause, Laura J.; Herrera, Maria Georgina; Winklhofer, Konstanze F.; The Role of Ubiquitin in Regulating Stress Granule Dynamics; Frontiers Media; Frontiers in Physiology; 13; 5-2022; 1-15
dc.identifier.issn
1664-042X
dc.identifier.uri
http://hdl.handle.net/11336/215550
dc.description.abstract
Stress granules (SGs) are dynamic, reversible biomolecular condensates, which assemble in the cytoplasm of eukaryotic cells under various stress conditions. Formation of SGs typically occurs upon stress-induced translational arrest and polysome disassembly. The increase in cytoplasmic mRNAs triggers the formation of a protein-RNA network that undergoes liquid-liquid phase separation when a critical interaction threshold has been reached. This adaptive stress response allows a transient shutdown of several cellular processes until the stress is removed. During the recovery from stress, SGs disassemble to re-establish cellular activities. Persistent stress and disease-related mutations in SG components favor the formation of aberrant SGs that are impaired in disassembly and prone to aggregation. Recently, posttranslational modifications of SG components have been identified as major regulators of SG dynamics. Here, we summarize new insights into the role of ubiquitination in affecting SG dynamics and clearance and discuss implications for neurodegenerative diseases linked to aberrant SG formation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FUS
dc.subject
G3BP
dc.subject
LLPS
dc.subject
SUMO
dc.subject
TDP-43
dc.subject
UBIQUITIN
dc.subject
VCP/P97
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The Role of Ubiquitin in Regulating Stress Granule Dynamics
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-19T14:33:00Z
dc.journal.volume
13
dc.journal.pagination
1-15
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Krause, Laura J.. Ruhr Universität Bochum; Alemania
dc.description.fil
Fil: Herrera, Maria Georgina. Ruhr Universität Bochum; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Winklhofer, Konstanze F.. Ruhr Universität Bochum; Alemania
dc.journal.title
Frontiers in Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fphys.2022.910759
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