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dc.contributor.author
Deco, Gustavo
dc.contributor.author
Sanz Perl Hernandez, Yonatan
dc.contributor.author
Bocaccio, Hernan
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Tagliazucchi, Enzo Rodolfo
dc.contributor.author
Kringelbach, Morten L.
dc.date.available
2023-10-20T14:13:37Z
dc.date.issued
2022-06
dc.identifier.citation
Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Bocaccio, Hernan; Tagliazucchi, Enzo Rodolfo; Kringelbach, Morten L.; The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states; Nature Research; Communications Biology; 5; 1; 6-2022; 1-13
dc.identifier.uri
http://hdl.handle.net/11336/215541
dc.description.abstract
Finding precise signatures of different brain states is a central, unsolved question in neuroscience. We reformulated the problem to quantify the ‘inside out’ balance of intrinsic and extrinsic brain dynamics in brain states. The difference in brain state can be described as differences in the detailed causal interactions found in the underlying intrinsic brain dynamics. We used a thermodynamics framework to quantify the breaking of the detailed balance captured by the level of asymmetry in temporal processing, i.e. the arrow of time. Specifically, the temporal asymmetry was computed by the time-shifted correlation matrices for the forward and reversed time series, reflecting the level of non-reversibility/non-equilibrium. We found precise, distinguishing signatures in terms of the reversibility and hierarchy of large-scale dynamics in three radically different brain states (awake, deep sleep and anaesthesia) in electrocorticography data from non-human primates. Significantly lower levels of reversibility were found in deep sleep and anaesthesia compared to wakefulness. Non-wakeful states also showed a flatter hierarchy, reflecting the diversity of the reversibility across the brain. Overall, this provides signatures of the breaking of detailed balance in different brain states, perhaps reflecting levels of conscious awareness.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Reversibility
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Time
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Cognition
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Neuroimaging
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Otras Ciencias Físicas
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Ciencias Físicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T22:25:38Z
dc.identifier.eissn
2399-3642
dc.journal.volume
5
dc.journal.number
1
dc.journal.pagination
1-13
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia
dc.description.fil
Fil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Bocaccio, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
dc.description.fil
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; Chile
dc.description.fil
Fil: Kringelbach, Morten L.. University Aarhus; Dinamarca. University of Oxford; Reino Unido
dc.journal.title
Communications Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-022-03505-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1038/s42003-022-03505-7
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