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dc.contributor.author
Rosli, Nur Ayshah  
dc.contributor.author
Islan, German Abel  
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Hasham, Rosnani  
dc.contributor.author
Castro, Guillermo Raul  
dc.contributor.author
Aziz, Azila Abdul  
dc.date.available
2023-10-18T15:00:36Z  
dc.date.issued
2022-09  
dc.identifier.citation
Rosli, Nur Ayshah; Islan, German Abel; Hasham, Rosnani; Castro, Guillermo Raul; Aziz, Azila Abdul; Incorporation of Nanoparticles Based on Zingiber Officinale Essential Oil into Alginate Films for Sustained Release; Penerbit Universiti Sains Malaysia; Journal of Physical Science; 33; 2; 9-2022; 107-124  
dc.identifier.issn
1675-3402  
dc.identifier.uri
http://hdl.handle.net/11336/215360  
dc.description.abstract
This research focused on the formulation of Ca2+ cross-linked alginate (Alg) gels containing Zingiber officinale oil extract (ZOE) loaded into a nanostructured lipid carrier (NLC). The NLC is intended to protect the Zingiber officinale oil against physical and chemical degradation during topical administration to sustain the drug release and reduce drug leakage during storage. The NLC was prepared using hot homogenisation and ultrasonication of glyceryl monostearate. Virgin coconut oil was used as the liquid lipid. The NLC-ZOE had a mean size diameter of 100 nm and a zeta potential value of −40 mV. The ZOE released from NLC followed the Korsmeyer-Peppas model case I (Fickian diffusion). The NLC-ZOE formulation was then incorporated into Alg. The gels were prepared via ionotropic gelation in the presence of calcium. Scanning electron microscopy (SEM) images of Alg films revealed successful intercalation of NLC within the Alg matrix. The in vitro ZOE release from NLC-ZOEAlg occurred in a sustained manner from the cross-linked Alg hydrogels compared to the free NLC. The profiles of NLC-ZOE released from the Alg films depended on the nanoparticles amount. The results demonstrated the importance of designing a local delivery system to entrap and control the release of the bioactive components of ZOE from within the Alg matrix. Ca2+ cross-linked Alg gels containing ZOE loaded into NLC was found to be suitable for topical delivery applications, as shown by the sustained release of ZOE from calcium cross-linked Alg films containing NLC that was demonstrated in this study.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Penerbit Universiti Sains Malaysia  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ALGINATE  
dc.subject
CONTROLLED RELEASE  
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DRUG DELIVERY  
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HYDROPHILIC POLYMER  
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NANOSTRUCTURED LIPID CARRIER  
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ZINGIBER OFFICINALE  
dc.subject.classification
Biotecnología relacionada con la Salud  
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Biotecnología de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Incorporation of Nanoparticles Based on Zingiber Officinale Essential Oil into Alginate Films for Sustained Release  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-31T15:12:02Z  
dc.identifier.eissn
2180-4230  
dc.journal.volume
33  
dc.journal.number
2  
dc.journal.pagination
107-124  
dc.journal.pais
Malasia  
dc.description.fil
Fil: Rosli, Nur Ayshah. Universiti Sains Malaysia; Malasia  
dc.description.fil
Fil: Islan, German Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina  
dc.description.fil
Fil: Hasham, Rosnani. Universiti Teknologi Malaysia; Malasia  
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Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina. Universidad Federal do Abc; Brasil  
dc.description.fil
Fil: Aziz, Azila Abdul. Universiti Teknologi Malaysia; Malasia  
dc.journal.title
Journal of Physical Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://jps.usm.my/wp-content/uploads/2022/08/JPS-332_Art-7-107-124.pdf  
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.21315/jps2022.33.2.7