Mostrar el registro sencillo del ítem

dc.contributor.author
Repizo, Guillermo Daniel  
dc.contributor.author
Gagné, Stéphanie  
dc.contributor.author
Foucault Grunenwald, Marie Laure  
dc.contributor.author
Borges, Vitor  
dc.contributor.author
Charpentier, Xavier  
dc.contributor.author
Limansky, Adriana Sara  
dc.contributor.author
Gomes, João Paulo  
dc.contributor.author
Viale, Alejandro Miguel  
dc.contributor.author
Salcedo, Suzana P.  
dc.date.available
2017-07-28T17:55:32Z  
dc.date.issued
2015-09  
dc.identifier.citation
Repizo, Guillermo Daniel; Gagné, Stéphanie; Foucault Grunenwald, Marie Laure; Borges, Vitor; Charpentier, Xavier; et al.; Differential Role of the T6SS in Acinetobacter baumannii Virulence; Public Library Of Science; Plos One; 10; 9; 9-2015; 1-20; e0138265  
dc.identifier.issn
1932-6203  
dc.identifier.uri
http://hdl.handle.net/11336/21530  
dc.description.abstract
Gram-negative bacteria, such as Acinetobacter baumannii, are an increasing burden in hospitals worldwide with an alarming spread of multi-drug resistant (MDR) strains. Herein, we compared a type strain (ATCC17978), a non-clinical isolate (DSM30011) and MDR strains of A. baumannii implicated in hospital outbreaks (Ab242, Ab244 and Ab825), revealing distinct patterns of type VI secretion system (T6SS) functionality. The T6SS genomic locus is present and was actively transcribed in all of the above strains. However, only the A. baumannii DSM30011 strain was capable of killing Escherichia coli in a T6SS-dependent manner, unlike the clinical isolates, which failed to display an active T6SS in vitro. In addition, DSM30011 was able to outcompete ATCC17978 as well as Pseudomonas aeruginosa and Klebsiella pneumoniae, bacterial pathogens relevant in mixed nosocomial infections. Finally, we found that the T6SS of DSM30011 is required for host colonization of the model organism Galleria mellonella suggesting that this system could play an important role in A. baumannii virulence in a strain-specific manner.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Public Library Of Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Acinetobacter Baumannii  
dc.subject
Virulence  
dc.subject
T6ss  
dc.subject
Bacterial Dueling  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Differential Role of the T6SS in Acinetobacter baumannii Virulence  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-11-24T19:36:56Z  
dc.journal.volume
10  
dc.journal.number
9  
dc.journal.pagination
1-20; e0138265  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
San Francisco  
dc.description.fil
Fil: Repizo, Guillermo Daniel. Université Claude Bernard Lyon 1; Francia  
dc.description.fil
Fil: Gagné, Stéphanie. Université Claude Bernard Lyon 1; Francia  
dc.description.fil
Fil: Foucault Grunenwald, Marie Laure. Université Claude Bernard Lyon 1; Francia  
dc.description.fil
Fil: Borges, Vitor. National Institute of Health; Portugal  
dc.description.fil
Fil: Charpentier, Xavier. Université Claude Bernard Lyon 1; Francia  
dc.description.fil
Fil: Limansky, Adriana Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina  
dc.description.fil
Fil: Gomes, João Paulo. National Institute of Health; Portugal  
dc.description.fil
Fil: Viale, Alejandro Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina  
dc.description.fil
Fil: Salcedo, Suzana P.. Université Claude Bernard Lyon 1; Francia  
dc.journal.title
Plos One  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0138265  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138265