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dc.contributor.author
Repizo, Guillermo Daniel
dc.contributor.author
Gagné, Stéphanie
dc.contributor.author
Foucault Grunenwald, Marie Laure
dc.contributor.author
Borges, Vitor
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Charpentier, Xavier
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Limansky, Adriana Sara
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Gomes, João Paulo
dc.contributor.author
Viale, Alejandro Miguel
dc.contributor.author
Salcedo, Suzana P.
dc.date.available
2017-07-28T17:55:32Z
dc.date.issued
2015-09
dc.identifier.citation
Repizo, Guillermo Daniel; Gagné, Stéphanie; Foucault Grunenwald, Marie Laure; Borges, Vitor; Charpentier, Xavier; et al.; Differential Role of the T6SS in Acinetobacter baumannii Virulence; Public Library Of Science; Plos One; 10; 9; 9-2015; 1-20; e0138265
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/21530
dc.description.abstract
Gram-negative bacteria, such as Acinetobacter baumannii, are an increasing burden in hospitals worldwide with an alarming spread of multi-drug resistant (MDR) strains. Herein, we compared a type strain (ATCC17978), a non-clinical isolate (DSM30011) and MDR strains of A. baumannii implicated in hospital outbreaks (Ab242, Ab244 and Ab825), revealing distinct patterns of type VI secretion system (T6SS) functionality. The T6SS genomic locus is present and was actively transcribed in all of the above strains. However, only the A. baumannii DSM30011 strain was capable of killing Escherichia coli in a T6SS-dependent manner, unlike the clinical isolates, which failed to display an active T6SS in vitro. In addition, DSM30011 was able to outcompete ATCC17978 as well as Pseudomonas aeruginosa and Klebsiella pneumoniae, bacterial pathogens relevant in mixed nosocomial infections. Finally, we found that the T6SS of DSM30011 is required for host colonization of the model organism Galleria mellonella suggesting that this system could play an important role in A. baumannii virulence in a strain-specific manner.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library Of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acinetobacter Baumannii
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Virulence
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T6ss
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Bacterial Dueling
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Differential Role of the T6SS in Acinetobacter baumannii Virulence
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T19:36:56Z
dc.journal.volume
10
dc.journal.number
9
dc.journal.pagination
1-20; e0138265
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Repizo, Guillermo Daniel. Université Claude Bernard Lyon 1; Francia
dc.description.fil
Fil: Gagné, Stéphanie. Université Claude Bernard Lyon 1; Francia
dc.description.fil
Fil: Foucault Grunenwald, Marie Laure. Université Claude Bernard Lyon 1; Francia
dc.description.fil
Fil: Borges, Vitor. National Institute of Health; Portugal
dc.description.fil
Fil: Charpentier, Xavier. Université Claude Bernard Lyon 1; Francia
dc.description.fil
Fil: Limansky, Adriana Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Gomes, João Paulo. National Institute of Health; Portugal
dc.description.fil
Fil: Viale, Alejandro Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Salcedo, Suzana P.. Université Claude Bernard Lyon 1; Francia
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0138265
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138265
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