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dc.contributor.author
Boni, Silvia
dc.contributor.author
Marin, Gustavo Horacio
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dc.contributor.author
Campaña, Laura
dc.contributor.author
Marin, Lupe
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dc.contributor.author
Risso Patrón, Soledad
dc.contributor.author
Marin, Gina
dc.contributor.author
Gabriel, Fernanda
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Corso, Alejandra
dc.contributor.author
Garay, Valeria
dc.contributor.author
Limeres, Manuel
dc.date.available
2023-10-18T13:50:11Z
dc.date.issued
2022-02
dc.identifier.citation
Boni, Silvia; Marin, Gustavo Horacio; Campaña, Laura; Marin, Lupe; Risso Patrón, Soledad; et al.; Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina; Hindawi Publishing Corporation; Interdisciplinary Perspectives on Infectious Diseases; 2022; 2-2022; 1-7
dc.identifier.issn
1687-708X
dc.identifier.uri
http://hdl.handle.net/11336/215297
dc.description.abstract
Background. Irrational use of antimicrobials (ATMs) triggers microbial resistance (AMR) which has severe consequences for human health. ATM consumption varies among countries and within each territory. These data should be known, in order to perform local policies towards AMR reduction. This work aimed to expose the association of the level of consumption of carbapenems and fluoroquinolones with their resistance rates in Pseudomonas aeruginosa in Argentina. Method. Consumption of antimicrobials was expressed by defined daily dose (DDD)/1000 inhabitants for each ATM during one year period, discriminating by each country region. Resistance of P. aeruginosa to carbapenems/fluoroquinolones groups was recorded. Consumption/resistance ratio "R"was calculated for each region of the country, comparing results with other countries. Results. P. aeruginosa resistance rate to fluoroquinolone (F) was 26.4% in blood samples and 29.7% in urine samples, whereas resistance rates to carbapenems (C) were 19.9 and 17.7% in blood and urine, respectively. Correlation between consumption and resistance was demonstrated for both antimicrobials (C: R = 0.58; p=0.003 and F: R = 0.77; p=0.0001). Great fluctuations of resistance levels were seen among regions within the country, always correlating resistance with areas in which a higher level of ATM consumption was detected. Conclusion. P. aeruginosa resistance to fluoroquinolone/carbapenems in Argentina directly correlated with antimicrobial consumption levels. A great heterogeneity in resistance profile was observed among areas where ATMs were widely used. Global data at the national level might mask local realities that require specific health policies in order to control the irrational use of ATMs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
antimicrobials
dc.subject
Fluoroquinolones
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Carbapenems
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Resistance Rates
dc.subject.classification
Farmacología y Farmacia
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-17T12:16:30Z
dc.identifier.eissn
1687-7098
dc.journal.volume
2022
dc.journal.pagination
1-7
dc.journal.pais
Canadá
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dc.journal.ciudad
Vancouver
dc.description.fil
Fil: Boni, Silvia. No especifíca;
dc.description.fil
Fil: Marin, Gustavo Horacio. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
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Fil: Campaña, Laura. No especifíca;
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Fil: Marin, Lupe. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
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Fil: Risso Patrón, Soledad. No especifíca;
dc.description.fil
Fil: Marin, Gina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Gabriel, Fernanda. No especifíca;
dc.description.fil
Fil: Corso, Alejandra. No especifíca;
dc.description.fil
Fil: Garay, Valeria. No especifíca;
dc.description.fil
Fil: Limeres, Manuel. No especifíca;
dc.journal.title
Interdisciplinary Perspectives on Infectious Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ipid/2022/3924212/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2022/3924212
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