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dc.contributor.author
Wedemeyer, Carolina
dc.contributor.author
Elgoyhen, Ana Belen
dc.contributor.author
Katz, Eleonora
dc.date.available
2023-10-17T11:46:23Z
dc.date.issued
2014
dc.identifier.citation
Activation of presynaptic GABAB receptors enables sustained transmission at high rate of stimulation in cholinergic olivocochlear-hair cell synapses; XXIX Annual Meeting and SAN-ISN Small Conference and Course; Huerta Grande; Argentina; 2014; 1-1
dc.identifier.uri
http://hdl.handle.net/11336/215104
dc.description.abstract
During development, medial olivocochlear (MOC) neurons transiently innervate cochlear inner hair cells (IHCs). Although acetylcholine is the main neurotransmitter at this synapse, an abundant GABA innervation is also present. Electrical stimulation of efferent fibers triggers the release of acetylcholine, but also activates presynaptic GABAB receptors, that in turn reduce the amount of ACh release. The mechanism of action of GABA is through the inhibition of P/Q type Ca2+ channels. We are now studying the consequences of GABAB-mediated inhibition in the short-term plasticity properties of this synapse. Inhibitory synaptic currents (IPSC) were recorded in IHCs of acutely isolated organs of Corti at P9-P11 while MOC fibers were electrically stimulated. In control conditions, 15 pulses applied at high frequency (50 or 100 Hz) resulted in a progressive decrease in IPSC amplitudes. At 50 Hz, the depression rate was 32% whereas it increased to 53% at 100 Hz. At low-frequency (10 Hz), the specific GABAB agonist, baclofen, reduced the amplitude of IPSCs throughout the train. However, at higher stimulus rates, IPSCs were always larger than controls with a maximal enhancement of 43% for the last IPSC of the train at 100 Hz. These results suggest that by reducing synaptic depression, activation of GABAB receptors would enable sustained transmission during high-frequency stimulation at the MOC-inner hair cell synapse.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Argentina de Investigación en Neurociencias
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COCHLEA
dc.subject
INNER HAIR CELLS
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SYNAPTIC PLASTICITY
dc.subject.classification
Biología del Desarrollo
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Activation of presynaptic GABAB receptors enables sustained transmission at high rate of stimulation in cholinergic olivocochlear-hair cell synapses
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2023-09-15T12:50:06Z
dc.journal.pagination
1-1
dc.journal.pais
Argentina
dc.journal.ciudad
Ciudad Autónoma de Buenos Aires
dc.description.fil
Fil: Wedemeyer, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Katz, Eleonora. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.saneurociencias.org.ar/wp-content/uploads/2012/12/Booklet_San2014_Digital.pdf
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.coverage
Nacional
dc.type.subtype
Reunión
dc.description.nombreEvento
XXIX Annual Meeting and SAN-ISN Small Conference and Course
dc.date.evento
2014-09-29
dc.description.ciudadEvento
Huerta Grande
dc.description.paisEvento
Argentina
dc.type.publicacion
Book
dc.description.institucionOrganizadora
Sociedad Argentina de Investigación en Neurosciencias
dc.source.libro
XXIX Annual Meeting and SAN-ISN Small Conference and Course
dc.date.eventoHasta
2014-10-03
dc.type
Reunión
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