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dc.contributor.author
García, Mónica Cristina  
dc.contributor.other
Gajbhiye, Virendra  
dc.contributor.other
Gajbhiye, Kavita R.  
dc.contributor.other
Hong, Seungpyo  
dc.date.available
2023-10-12T12:15:47Z  
dc.date.issued
2022  
dc.identifier.citation
García, Mónica Cristina; Stimuli-responsive nanogels as promising carriers for controlled drug delivery of anticancer therapeutics; Academic Press; 2022; 429-450  
dc.identifier.isbn
978-0-12-824456-2  
dc.identifier.uri
http://hdl.handle.net/11336/214989  
dc.description.abstract
Nanogels (NGs), especially those with stimuli responsiveness, have attracted significant attention in the last decades because of their potential for biomedical applications, particularly in the field of cancer therapy research. These nanoparticles are highly promising for therapeutic delivery because of their high biocompatibility with body fluids and tissues as well as their ability to encapsulate high amounts of biologically active agents such as drugs, proteins, and genetic material inside the polymer networks and release the payload in a controlled manner. The designed introduction of specific polymer modalities allows changing ordinary NGs into advanced stimuli-sensitive nanocarriers that undergo physicochemical transitions or chemical changes in their structure (e.g., change their conformation, size and charges, solubility, alter their hydrophilic/hydrophobic balance, or degrade chemical structures) in response to various endogenous and exogenous stimuli. While detecting changes in the tumor microenvironment (pH, enzymes, reactive oxygen species, redox conditions, etc.), NGs can release the payload at the target site without relying on costly systems that require an external source (e.g., magnetic field, light, temperature, etc.) to remotely trigger the release of the payload. The emphasis of this chapter is on the most recent contributions in the arena of endogenous stimuli-responsive NGs, including pH-sensitive, enzyme-sensitive, ROS-sensitive, redox-sensitive NGs, as they can directly detect changes in the internal microenvironment of cancer cells for triggering the release of anticancer therapeutics. Moreover, some dual or multiresponsive NGs that combine different internal and/or external stimuli such as magnetic-responsive, light-responsive, and temperature-responsive NGs are discussed. The biological barriers that need to be overcome for efficient delivery of anticancer therapeutics as well as the relevance of passive and active targeting are described. The fundamental understanding of their responsive behavior against various stimuli with applications in cancer therapy is highlighted, and their future prospective is also discussed.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Academic Press  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ENDOGENOUS STIMULI  
dc.subject
TRIGGERED DRUG RELEASE  
dc.subject
TUMOR MICROENVIRONMENT  
dc.subject
DRUG DELIVERY  
dc.subject
CANCER THERAPY  
dc.subject.classification
Otras Nanotecnología  
dc.subject.classification
Nanotecnología  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Stimuli-responsive nanogels as promising carriers for controlled drug delivery of anticancer therapeutics  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2023-07-21T13:10:18Z  
dc.journal.pagination
429-450  
dc.journal.pais
Reino Unido  
dc.description.fil
Fil: García, Mónica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/B9780128244562000059  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/B978-0-12-824456-2.00005-9  
dc.conicet.paginas
485  
dc.source.titulo
Stimuli-responsive nanocarriers: Recent advances in Tailor-Made therapeutics