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dc.contributor.author
Marziali, Federico Emanuel
dc.contributor.author
Cavatorta, Ana Laura
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Bugnon Valdano, Marina Paula
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Facciuto, Florencia Natalia
dc.contributor.author
Gardiol, Daniela Nora
dc.date.available
2017-07-27T18:02:59Z
dc.date.issued
2015-03
dc.identifier.citation
Marziali, Federico Emanuel; Cavatorta, Ana Laura; Bugnon Valdano, Marina Paula; Facciuto, Florencia Natalia; Gardiol, Daniela Nora; Transcriptional and translational mechanisms contribute to regulate the expression of Discs Large 1 protein during different biological processes; de Gruyter; Biological Chemistry; 396; 8; 3-2015; 1-10
dc.identifier.issn
1431-6730
dc.identifier.uri
http://hdl.handle.net/11336/21474
dc.description.abstract
Human discs large (DLG1) has been demonstrated to be involved in cell polarity and maintenance of tissue architecture. However, the mechanisms controlling DLG1 expression are not fully understood. This is relevant as DLG1 is lost during the later stages of malignant progression. We initiated a series of studies to analyse the mechanisms regulating DLG1 expression. We have previously reported the identification of an alternative splicing event in the 5 ′ untranslated region (5 ′ -UTR) of DLG1 mRNA that generates transcripts with two different 5 ′ -UTR (short and large 5 ′ -UTR variants). In this study, we further examined the impact of the DLG1 transcription and the role of the differential expression of the alternative 5 ′ -UTRs on DLG1 protein levels. We analysed these mechanisms during cell processes like differentiation, cell cycle progression and cell-cell contact formation, where the importance of DLG1 activities was previously established. The data presented in this report suggest that the transcriptional regulation of DLG1 strongly contributes to DLG1 abundance and that differential expression of alternative 5 ′ -UTRs with different translational properties, also cooperates, depending on the cell type and cell situation. This study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
de Gruyter
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dlg1
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Expression
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Polarity
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Transcription Regulation
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5' Utr
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Transcriptional and translational mechanisms contribute to regulate the expression of Discs Large 1 protein during different biological processes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T19:36:43Z
dc.identifier.eissn
1437-4315
dc.journal.volume
396
dc.journal.number
8
dc.journal.pagination
1-10
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Marziali, Federico Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Cavatorta, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Bugnon Valdano, Marina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Facciuto, Florencia Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Gardiol, Daniela Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.journal.title
Biological Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/hsz-2014-0286
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/bchm.2015.396.issue-8/hsz-2014-0286/hsz-2014-0286.xml
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