Mostrar el registro sencillo del ítem
dc.contributor.author
Silva Sofrás, Fresia Melina
dc.contributor.author
Desimone, Martín Federico
dc.date.available
2023-10-10T16:01:22Z
dc.date.issued
2022-11
dc.identifier.citation
Silva Sofrás, Fresia Melina; Desimone, Martín Federico; Entourage Effect And Analytical Chemistry: Chromatography As A Tool In The Analysis Of The Secondary Metabolism Of Cannabis Sativa L; Bentham Science Publishers; Current Pharmaceutical Design; 29; 6; 11-2022; 394-406
dc.identifier.issn
1381-6128
dc.identifier.uri
http://hdl.handle.net/11336/214722
dc.description.abstract
Cannabis sativa L. has been used as medicine for thousands of years. Since the early identification of tetrahydrocannabinol (THC) in 1960, pharmacological activities were attributed to a group of unique structures named cannabinoids. For decades, research and development were applied to determine different cannabinoids and their medicinal properties. Nowadays there is evidence that the therapeutic benefits of the plant are based on the synergy of cannabinoids and other secondary metabolites such as terpenes and flavonoids. Differences between the medical performance of isolated compounds like cannabidiol (CBD) or THC and full-spectrum plant extracts are notable. Indeed, the superiority of the last one is provoked by the synergy between various different compounds. This improved medicinal effect is called the entourage effect. Chromatography has be-come the method of choice for the determination of cannabinoids, terpenes, and flavonoids, so it represents an excellent tool for a proper characterization of the plant and plant derived products. The objective of characterization relies not only in analyzing the fingerprint of cannabis, but also to identify different chemotypes for medical purposes. To understand the contributions of each natural product to this “entourage effect”, this review presents an in-depth analysis of the utilization of High-performance liquid chromatography (HPLC), Gas chromatography (GC) and other methods for the analysis of phytocomponents of Cannabis sativa L. In this sense, a representative number of examples and advances made in the field together with limitations and future needs are provided. It can be concluded that standardized protocols and quality control policies and procedures are necessary for the comprehensive analysis of cannabis extracts and derivatives.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CANNABINOIDS
dc.subject
CANNABIS
dc.subject
CHEMOTYPES
dc.subject
CHROMATOGRAPHY
dc.subject
ENTOURAGE EFFECT
dc.subject
INFLORESCENCES
dc.subject
MEDICINAL PLANT
dc.subject
SYNERGY
dc.subject
TRICHOMES
dc.subject.classification
Química Analítica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Entourage Effect And Analytical Chemistry: Chromatography As A Tool In The Analysis Of The Secondary Metabolism Of Cannabis Sativa L
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T22:55:29Z
dc.journal.volume
29
dc.journal.number
6
dc.journal.pagination
394-406
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Silva Sofrás, Fresia Melina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Desimone, Martín Federico. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.journal.title
Current Pharmaceutical Design
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/210583/article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1381612829666221103093542
Archivos asociados