Artículo
How do you feel when you can't feel your body?: Interoception, functional connectivity and emotional processing in Depersonalization-Derealization Disorder
Sedeño, Lucas
; Couto, Juan Blas Marcos
; Melloni, Margherita
; Canales Johnson, Andrés; Yoris, Adrián; Báez Buitrago, Sandra Jimena
; Esteves, Sol; Velásquez, Marcela; Barttfeld, Pablo
; Sigman, Mariano
; Kichic, Rafael; Chialvo, Dante Renato
; Manes, Facundo Francisco
; Bekinschtein, Tristán Andrés
; Ibañez, Agustin Mariano
Fecha de publicación:
06/2014
Editorial:
Public Library of Science
Revista:
Plos One
ISSN:
1932-6203
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception −defined as the cognitive processing of body signals− has been extensively considered as a key processing for body self-awareness. In consequence, the purpose of this study was to investigate whether there are systematic differences in interoception between a patient with DD and controls that might explain the disembodiment symptoms suffered in this disease. To assess interoception, we utilized a heartbeat detection task and measures of functional connectivity derived from fMRI networks in interoceptive/exteroceptivo/mind-wandering states. Additionally, we evaluated empathic abilities to test the association between interoception and emotional experience. The results showed patient's impaired performance in the heartbeat detection task when compared to controls. Furthermore, regarding functional connectivity, we found a lower global brain connectivity of the patient relative to controls only in the interoceptive state. He also presented a particular pattern of impairments in affective empathy. To our knowledge, this is the first experimental research that assesses the relationship between interoception and DD combining behavioral and neurobiological measures. Our results suggest that altered neural mechanisms and cognitive processes regarding body signaling might be engaged in DD phenomenology. Moreover, our study contributes experimental data to the comprehension of brain-body interactions and the emergence of self-awareness and emotional feelings.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Sedeño, Lucas; Couto, Juan Blas Marcos; Melloni, Margherita; Canales Johnson, Andrés; Yoris, Adrián; et al.; How do you feel when you can't feel your body?: Interoception, functional connectivity and emotional processing in Depersonalization-Derealization Disorder; Public Library of Science; Plos One; 9; 6; 6-2014; 1-17; e98769
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