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dc.contributor.author
Tolomeo, Anna Maria
dc.contributor.author
Fabozzo, Assunta
dc.contributor.author
Malvicini, Ricardo
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dc.contributor.author
De Lazzari, Giada
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Bisaccia, Paola
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Gaburro, Gianluca
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Arcidiacono, Diletta
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Notarangelo, Denni
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Caicci, Federico
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Zanella, Fabio
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Marchesan, Massimo
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Yannarelli, Gustavo Gabriel
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Santovito, Gianfranco
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Muraca, Maurizio
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Gerosa, Gino
dc.date.available
2023-10-09T12:06:59Z
dc.date.issued
2022-02
dc.identifier.citation
Tolomeo, Anna Maria; Fabozzo, Assunta; Malvicini, Ricardo; De Lazzari, Giada; Bisaccia, Paola; et al.; Temperature-Related Effects of Myocardial Protection Strategies in Swine Hearts after Prolonged Warm Ischemia; MDPI; Antioxidants; 11; 3; 2-2022; 1-17
dc.identifier.issn
2076-3921
dc.identifier.uri
http://hdl.handle.net/11336/214460
dc.description.abstract
Insufficient supply of cardiac grafts represents a severe obstacle in heart transplantation. Donation after circulatory death (DCD), in addition to conventional donation after brain death, is one promising option to overcome the organ shortage. However, DCD organs undergo an inevitably longer period of unprotected warm ischemia between circulatory arrest and graft procurement. In this scenario, we aim to improve heart preservation after a warm ischemic period of 20 min by testing different settings of myocardial protective strategies. Pig hearts were collected from a slaughterhouse and assigned to one of the five experimental groups: baseline (BL), cold cardioplegia (CC), cold cardioplegia + adenosine (CC-ADN), normothermic cardioplegia (NtC + CC) or normothermic cardioplegia + cold cardioplegia + adenosine (NtC-ADN + CC). After treatment, tissue biopsies were taken to assess mitochondrial morphology, antioxidant enzyme activity, lipid peroxidation and cytokine and chemokine expressions. NtC + CC treatment significantly prevented mitochondria swelling and mitochondrial cristae loss. Moreover, the antioxidant enzyme activity was lower in this group, as was lipid peroxidation, and the pro-inflammatory chemokine GM-CSF was diminished. Finally, we demonstrated that normothermic cardioplegia preserved mitochondria morphology, thus preventing oxidative stress and the subsequent inflammatory response. Therefore, normothermic cardioplegia is a better approach to preserve the heart after a warm ischemia period, with respect to cold cardioplegia, before transplantation.
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application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
DONATION AFTER CIRCULATORY DEATH
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ENRICHED CARDIOPLEGIA
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ORGAN RECONDITIONING
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OXIDATIVE STRESS
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TRANSPLANTATION
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Trasplantes
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Temperature-Related Effects of Myocardial Protection Strategies in Swine Hearts after Prolonged Warm Ischemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-05T12:58:06Z
dc.journal.volume
11
dc.journal.number
3
dc.journal.pagination
1-17
dc.journal.pais
Suiza
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dc.description.fil
Fil: Tolomeo, Anna Maria. Università di Padova; Italia
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Fil: Fabozzo, Assunta. Università di Padova; Italia
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Fil: Malvicini, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
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Fil: De Lazzari, Giada. Università di Padova; Italia
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Fil: Bisaccia, Paola. Università di Padova; Italia
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Fil: Gaburro, Gianluca. Università di Padova; Italia
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Fil: Arcidiacono, Diletta. Veneto Institute of Oncology; Italia
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Fil: Notarangelo, Denni. Università di Padova; Italia
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Fil: Caicci, Federico. Università di Padova; Italia
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Fil: Zanella, Fabio. Università di Padova; Italia
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Fil: Marchesan, Massimo. No especifíca;
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Fil: Yannarelli, Gustavo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
dc.description.fil
Fil: Santovito, Gianfranco. Università di Padova; Italia
dc.description.fil
Fil: Muraca, Maurizio. Università di Padova; Italia
dc.description.fil
Fil: Gerosa, Gino. Università di Padova; Italia
dc.journal.title
Antioxidants
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3921/11/3/476
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/antiox11030476
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