A physiological concentration of anandamide promotes the migration of human endometrial fibroblast and the interaction with endothelial cells in vitro

The mechanisms that govern fibroblast behavior during the vascular adaptations of the uterus at early pregnancy remain unknown. Anandamide, an endocannabinoid, binds to cannabinoid receptors (CBs), and regulates gestation and angiogenesis. Its tone is regulated by fatty acid amide hydrolase (FAAH) within the uterus. We investigated the role of anandamide in endometrial fibroblasts migration and whether anandamide modulates fibroblasts-endothelial crosstalk.

Palabras clave: ANANDAMIDE , ENDOMETRIUM , ENDOTHELIAL CELLS , MIGRATION , STROMAL FIBROBLASTS , VASCULAR REMODELING

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)

Identificadores

URI: http://hdl.handle.net/11336/214368

URL: https://linkinghub.elsevier.com/retrieve/pii/S0143400423001327

DOI: http://dx.doi.org/10.1016/j.placenta.2023.06.004

Colecciones

Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS

Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Cañumil, Vanesa Alejandra; de la Cruz Borthiry, Fernanda Luz; Scheffer, Frida; Herrero, Yamila; Scotti, Leopoldina; et al.; A physiological concentration of anandamide promotes the migration of human endometrial fibroblast and the interaction with endothelial cells in vitro; W B Saunders Co Ltd; Placenta; 139; 8-2023; 99-111

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