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dc.contributor.author
Stuart, Tucker
dc.contributor.author
Jeang, William J.
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Slivicki, Richard A.
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Brown, Bobbie J.
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Burton, Alex
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Brings, Victoria E.
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Agyare, Prophecy
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Alarcon Segovia, Lilian Celeste
dc.contributor.author
Ruiz, Savanna
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Tyree, Amanda
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Pruitt, Lindsay
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Madhvapathy, Surabhi
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Niemiec, Martin
dc.contributor.author
Zhuang, James
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Krishnan, Siddharth
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Copits, Bryan A.
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Rogers, John A.
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Gereau, Robert W.
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Samineni, Vijay K.
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Bandodkar, Amay J.
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Gutruf, Philipp
dc.date.available
2023-10-06T14:33:05Z
dc.date.issued
2022-12
dc.identifier.citation
Stuart, Tucker; Jeang, William J.; Slivicki, Richard A.; Brown, Bobbie J.; Burton, Alex; et al.; Wireless, Battery-Free Implants for Electrochemical Catecholamine Sensing and Optogenetic Stimulation; American Chemical Society; ACS Nano; 17; 1; 12-2022; 561-574
dc.identifier.issn
1936-0851
dc.identifier.uri
http://hdl.handle.net/11336/214360
dc.description.abstract
Neurotransmitters and neuromodulators mediate communication between neurons and other cell types; knowledge of release dynamics is critical to understanding their physiological role in normal and pathological brain function. Investigation into transient neurotransmitter dynamics has largely been hindered due to electrical and material requirements for electrochemical stimulation and recording. Current systems require complex electronics for biasing and amplification and rely on materials that offer limited sensor selectivity and sensitivity. These restrictions result in bulky, tethered, or battery-powered systems impacting behavior and that require constant care of subjects. To overcome these challenges, we demonstrate a fully implantable, wireless, and battery-free platform that enables optogenetic stimulation and electrochemical recording of catecholamine dynamics in real time. The device is nearly 1/10th the size of previously reported examples and includes a probe that relies on a multilayer electrode architecture featuring a microscale light emitting diode (μ-LED) and a carbon nanotube (CNT)-based sensor with sensitivities among the highest recorded in the literature (1264.1 nA μM-1 cm-2). High sensitivity of the probe combined with a center tapped antenna design enables the realization of miniaturized, low power circuits suitable for subdermal implantation even in small animal models such as mice. A series of in vitro and in vivo experiments highlight the sensitivity and selectivity of the platform and demonstrate its capabilities in freely moving, untethered subjects. Specifically, a demonstration of changes in dopamine concentration after optogenetic stimulation of the nucleus accumbens and real-time readout of dopamine levels after opioid and naloxone exposure in freely behaving subjects highlight the experimental paradigms enabled by the platform.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BATTERY-FREE
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CARBON NANOTUBES
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CATECHOLAMINE
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DOPAMINE
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OPTOGENETICS
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WIRELESS
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Ingeniería Médica
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Ingeniería Médica
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Wireless, Battery-Free Implants for Electrochemical Catecholamine Sensing and Optogenetic Stimulation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T21:56:06Z
dc.journal.volume
17
dc.journal.number
1
dc.journal.pagination
561-574
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Stuart, Tucker. University of Arizona; Estados Unidos
dc.description.fil
Fil: Jeang, William J.. Northwestern University; Estados Unidos
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Fil: Slivicki, Richard A.. University of Washington; Estados Unidos
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Fil: Brown, Bobbie J.. University of Washington; Estados Unidos
dc.description.fil
Fil: Burton, Alex. University of Arizona; Estados Unidos
dc.description.fil
Fil: Brings, Victoria E.. University of Washington; Estados Unidos
dc.description.fil
Fil: Agyare, Prophecy. Northwestern University; Estados Unidos
dc.description.fil
Fil: Alarcon Segovia, Lilian Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina
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Fil: Ruiz, Savanna. Northwestern University; Estados Unidos
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Fil: Tyree, Amanda. University of Arizona; Estados Unidos
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Fil: Pruitt, Lindsay. University of Arizona; Estados Unidos
dc.description.fil
Fil: Madhvapathy, Surabhi. Northwestern University; Estados Unidos
dc.description.fil
Fil: Niemiec, Martin. University of Arizona; Estados Unidos
dc.description.fil
Fil: Zhuang, James. University of Arizona; Estados Unidos
dc.description.fil
Fil: Krishnan, Siddharth. Northwestern University; Estados Unidos
dc.description.fil
Fil: Copits, Bryan A.. University of Washington; Estados Unidos
dc.description.fil
Fil: Rogers, John A.. Northwestern University; Estados Unidos
dc.description.fil
Fil: Gereau, Robert W.. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Samineni, Vijay K.. University of Washington; Estados Unidos
dc.description.fil
Fil: Bandodkar, Amay J.. No especifíca;
dc.description.fil
Fil: Gutruf, Philipp. University of Arizona; Estados Unidos
dc.journal.title
ACS Nano
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/acsnano.2c09475
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acsnano.2c09475
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