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dc.contributor.author
Kratz, Jadel M.  
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Gonçalves, Karolina R.  
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Romera, Lavínia M. D.  
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Borsoi Moraes, Carolina  
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Bittencourt Cunha, Paula  
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Schenkman, Sergio  
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Chatelain, Eric  
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Sosa-Estani, Sergio Alejandro  
dc.date.available
2023-10-06T10:53:58Z  
dc.date.issued
2022-05  
dc.identifier.citation
Kratz, Jadel M.; Gonçalves, Karolina R.; Romera, Lavínia M. D.; Borsoi Moraes, Carolina; Bittencourt Cunha, Paula; et al.; The translational challenge in chagas disease drug development; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 116; 1; 5-2022; 1-11  
dc.identifier.issn
0074-0276  
dc.identifier.uri
http://hdl.handle.net/11336/214296  
dc.description.abstract
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Fundação Oswaldo Cruz  
dc.rights
info:eu-repo/semantics/openAccess  
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https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ANIMAL MODEL  
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DORMANCY  
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IN VITRO ASSAY  
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PERSISTERS  
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PHARMACOKINETIC PHARMACODYNAMIC (PK/PD) RELATIONSHIP  
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TRYPANOSOMA CRUZI  
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Enfermedades Infecciosas  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
The translational challenge in chagas disease drug development  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-10T11:56:41Z  
dc.identifier.eissn
1678-8060  
dc.journal.volume
116  
dc.journal.number
1  
dc.journal.pagination
1-11  
dc.journal.pais
Brasil  
dc.description.fil
Fil: Kratz, Jadel M.. No especifíca;  
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Fil: Gonçalves, Karolina R.. Universidade de Sao Paulo; Brasil  
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Fil: Romera, Lavínia M. D.. Universidade de Sao Paulo; Brasil  
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Fil: Borsoi Moraes, Carolina. Universidade Federal de Sao Paulo; Brasil  
dc.description.fil
Fil: Bittencourt Cunha, Paula. Universidade de Sao Paulo; Brasil. Universidade Federal de Sao Paulo; Brasil  
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Fil: Schenkman, Sergio. Universidade Federal de Sao Paulo; Brasil  
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Fil: Chatelain, Eric. No especifíca;  
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Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina  
dc.journal.title
Memórias do Instituto Oswaldo Cruz  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/0074-02760200501