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dc.contributor.author
Raina, Dhruv
dc.contributor.author
Fabris, Fiorella
dc.contributor.author
Morelli, Luis Guillermo
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Schroter, Christian
dc.date.available
2023-10-06T10:53:15Z
dc.date.issued
2022-02
dc.identifier.citation
Raina, Dhruv; Fabris, Fiorella; Morelli, Luis Guillermo; Schroter, Christian; Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells; Company of Biologists; Development; 149; 4; 2-2022; 1-39
dc.identifier.issn
0950-1991
dc.identifier.uri
http://hdl.handle.net/11336/214294
dc.description.abstract
Signal transduction networks generate characteristic dynamic activities to process extracellular signals and guide cell fate decisions such as to divide or differentiate. The differentiation of pluripotent cells is controlled by FGF/ERK signaling. However, only a few studies have addressed the dynamic activity of the FGF/ERK signaling network in pluripotent cells at high time resolution. Here, we use live cell sensors in wild-type and Fgf4-mutant mouse embryonic stem cells to measure dynamic ERK activity in single cells, for defined ligand concentrations and differentiation states. These sensors reveal pulses of ERK activity. Pulsing patterns are heterogeneous between individual cells. Consecutive pulse sequences occur more frequently than expected from simple stochastic models. Sequences become more prevalent with higher ligand concentration, but are rarer in more differentiated cells. Our results suggest that FGF/ERK signaling operates in the vicinity of a transition point between oscillatory and non-oscillatory dynamics in embryonic stem cells. The resulting heterogeneous dynamic signaling activities add a new dimension to cellular heterogeneity that may be linked to divergent fate decisions in stem cell cultures.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Company of Biologists
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CELL CYCLE
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FGF/ERK SIGNALING
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MOUSE EMBRYONIC STEM CELLS
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OSCILLATIONS
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SIGNAL TRANSDUCTION NETWORKS
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TIME SERIES ANALYSIS
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Biología del Desarrollo
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Otras Ciencias Físicas
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Ciencias Físicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-10T11:58:48Z
dc.journal.volume
149
dc.journal.number
4
dc.journal.pagination
1-39
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Raina, Dhruv. Institut Max Planck fur Molekulare Physiologie; Alemania
dc.description.fil
Fil: Fabris, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
dc.description.fil
Fil: Morelli, Luis Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Institut Max Planck fur Molekulare Physiologie; Alemania
dc.description.fil
Fil: Schroter, Christian. Institut Max Planck fur Molekulare Physiologie; Alemania
dc.journal.title
Development
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1242/dev.199710
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