Artículo
Edinger-Westphal peptidergic neurons enable maternal preparatory nesting
Topilko, Thomas; Diaz, Silvina Laura
; Pacheco, Catarina M.; Verny, Florine; Rousseau, Charly V.; Kirst, Christoph; Deleuze, Charlotte; Gaspar, Patricia; Renier, Nicolas
Fecha de publicación:
02/2022
Editorial:
Cell Press
Revista:
Neuron
ISSN:
0896-6273
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Optimizing reproductive fitness in mammalians requires behavioral adaptations during pregnancy. Maternal preparatory nesting is an essential behavior for the survival of the upcoming litter. Brain-wide immediate early gene mapping in mice evoked by nesting sequences revealed that phases of nest construction strongly activate peptidergic neurons of the Edinger-Westphal nucleus in pregnant mice. Genetic ablation, bidirectional neuromodulation, and in vitro and in vivo activity recordings demonstrated that these neurons are essential to modulate arousal before sleep to promote nesting specifically. We show that these neurons enable the behavioral effects of progesterone on preparatory nesting by modulating a broad network of downstream targets. Our study deciphers the role of midbrain CART+ neurons in behavioral adaptations during pregnancy vital for reproductive fitness.
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Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Citación
Topilko, Thomas; Diaz, Silvina Laura; Pacheco, Catarina M.; Verny, Florine; Rousseau, Charly V.; et al.; Edinger-Westphal peptidergic neurons enable maternal preparatory nesting; Cell Press; Neuron; 110; 8; 2-2022; 1385-1399.e8
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