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dc.contributor.author
Villalobos, Rafael
dc.contributor.author
Vidales, Ana Maria
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dc.contributor.author
Cordero, Salomón
dc.contributor.author
Quintanar, David
dc.contributor.author
Domínguez, Armando
dc.date.available
2023-10-05T13:41:05Z
dc.date.issued
2006-12
dc.identifier.citation
Villalobos, Rafael; Vidales, Ana Maria; Cordero, Salomón; Quintanar, David; Domínguez, Armando; Monte carlo simulation of diffusion-limited drug release from finite fractal matrices; Springer; Journal of Sol-Gel Science and Technology; 37; 3; 12-2006; 195-199
dc.identifier.issn
0928-0707
dc.identifier.uri
http://hdl.handle.net/11336/214213
dc.description.abstract
How fast can drug molecules escape from a controlled matrix-type release system? This important question is of both scientific and practical importance, as increasing emphasis is placed on design considerations that can be addressed only if the physical chemistry of drug release is better understood. In this work, this problem is studied via Monte Carlo computer simulations. The drug release is simulated as a diffusion-controlled process. Six types of Menger sponges (all having the same fractal dimension, d f = 2.727, but with different values of random walk dimension, d w ∈ [2.028, 2.998]) are employed as models of drug delivery devices with the aim of studying the consequences of matrix structural properties (characterized by d f and d w ) on drug release performance. The results obtained show that, in all cases, drug release from Menger sponges follows an anomalous behavior. Finally, the influence of the matrix structural properties on the drug release profile is quantified.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANOMALOUS DIFFUSION
dc.subject
DRUG RELEASE
dc.subject
FRACTAL DIMENSION
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MENGER SPONGE
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MONTE CARLO SIMULATION
dc.subject
RANDOM WALK DIMENSION
dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Monte carlo simulation of diffusion-limited drug release from finite fractal matrices
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T20:33:48Z
dc.journal.volume
37
dc.journal.number
3
dc.journal.pagination
195-199
dc.journal.pais
Alemania
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dc.description.fil
Fil: Villalobos, Rafael. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Vidales, Ana Maria. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
dc.description.fil
Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Quintanar, David. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Domínguez, Armando. Universidad Autónoma Metropolitana; México
dc.journal.title
Journal of Sol-Gel Science and Technology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10971-005-6628-8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10971-005-6628-8
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