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Artículo

Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse

Meyer, MariaIcon ; Gonzalez Deniselle, Maria ClaudiaIcon ; Gargiulo Monachelli, Gisella MarianaIcon ; Lima, Analia EthelIcon ; Roig, PaulinaIcon ; Guennoun, Rachida; Schumacher, Michael; de Nicola, Alejandro FedericoIcon
Fecha de publicación: 24/02/2013
Editorial: Wiley
Revista: Journal of Neuroendocrinology
ISSN: 1365-2826
e-ISSN: 1365-2826
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

It is now recognised that progesterone plays a protective role for diseases of the central nervous system. In the Wobbler mouse, a model of motoneurone degeneration, progesterone treatment prevents spinal cord neuropathology and clinical progression of the disease. However, neuropathological and functional abnormalities have also been discovered in the brain of Wobbler mice and patients with amyotrophic lateral sclerosis. The present study examined the hippocampus of control and afflicted Wobbler mice and the changes in response to progesterone treatment. Mice received either a single progesterone implant (20 mg for 18 days). We found that the hippocampal pathology of the untreated Wobblers involved a decreased expression of brain-derived neurotrophic factor (BDNF) mRNA, decreased astrogliosis in the stratum lucidum, stratum radiatum and stratum lacunosum-moleculare, decreased doublecortin (DCX)-positive neuroblasts in the subgranular zone of the dentate gyrus and a decreased density of GABA immunoreactive hippocampal interneurones and granule cells of the dentate gyrus. Although progesterone did not change the normal parameters of control mice, it attenuated several hippocampal abnormalities in Wobblers. Thus, progesterone increased hippocampal BDNF mRNA expression, decreased glial fibrillary acidic protein-positive astrocytes and increased the number of GABAergic interneurones and granule cells. The number of DCX expressing neuroblasts and immature neurones remained impaired in both progesterone-treated and untreated Wobblers. In conclusion, progesterone treatment exerted beneficial effects on some aspects of hippocampal neuropathology, suggesting its neuroprotective role in the brain, in agreement with previous data obtained in the spinal cord of Wobbler mice.
Palabras clave: Progesterone , Hippocampus , Wobbler , Central Nervous System , Bdnf
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/21413
DOI: http://dx.doi.org/10.1111/jne.12004
URL: http://onlinelibrary.wiley.com/doi/10.1111/jne.12004
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Meyer, Maria; Gonzalez Deniselle, Maria Claudia; Gargiulo Monachelli, Gisella Mariana; Lima, Analia Ethel; Roig, Paulina; et al.; Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse; Wiley; Journal of Neuroendocrinology; 25; 3; 24-2-2013; 235-243
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