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dc.contributor.author
Boudreau, Marc A.
dc.contributor.author
Fishovitz, Jennifer
dc.contributor.author
Llarrull, Leticia Irene
dc.contributor.author
Xiao, Qiaobin
dc.contributor.author
Mobashery, Shahriar
dc.date.available
2017-07-26T20:43:16Z
dc.date.issued
2015-08
dc.identifier.citation
Boudreau, Marc A.; Fishovitz, Jennifer; Llarrull, Leticia Irene; Xiao, Qiaobin; Mobashery, Shahriar; Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules; American Chemical Society; ACS Infectious Diseases; 1; 10; 8-2015; 454-459
dc.identifier.uri
http://hdl.handle.net/11336/21386
dc.description.abstract
Methicillin-resistant Staphylococcus aureus (MRSA), an important human pathogen, has evolved an inducible mechanism for resistance to β-lactam antibiotics. We report herein that the integral membrane protein BlaR1, the β- lactam sensor/signal transducer protein, is phosphorylated on exposure to β-lactam antibiotics. This event is critical to the onset of the induction of antibiotic resistance. Furthermore, we document that BlaR1 phosphorylation and the antibioticresistance phenotype are both reversed in the presence of synthetic protein kinase inhibitors of our design, restoring susceptibility of the organism to a penicillin, resurrecting it from obsolescence in treatment of these intransigent bacteria.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Blar1
dc.subject
Phosphorylation
dc.subject
Mrsa
dc.subject
Kinase Inhibitor
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Stk1
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T19:37:02Z
dc.identifier.eissn
2373-8227
dc.journal.volume
1
dc.journal.number
10
dc.journal.pagination
454-459
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Boudreau, Marc A.. University Of Notre Dame-Indiana; Estados Unidos
dc.description.fil
Fil: Fishovitz, Jennifer. University Of Notre Dame-Indiana; Estados Unidos
dc.description.fil
Fil: Llarrull, Leticia Irene. University Of Notre Dame-Indiana; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Xiao, Qiaobin. University Of Notre Dame-Indiana; Estados Unidos
dc.description.fil
Fil: Mobashery, Shahriar. University Of Notre Dame-Indiana; Estados Unidos
dc.journal.title
ACS Infectious Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acsinfecdis.5b00086
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsinfecdis.5b00086
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