Artículo
Regulation of the Expression of the β-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA)
Blázquez, Blas; Llarrull, Leticia Irene
; Luque Ortega, Juan R.; Alfonso, Carlos; Boggess, Bill; Mobashery, Shahriar
Fecha de publicación:
02/2014
Editorial:
American Chemical Society
Revista:
Biochemistry
ISSN:
0006-2960
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
β-Lactam antibiotics have faced obsolescence with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). A complex set of events ensues upon exposure of MRSA to these antibiotics, which culminates in proteolysis of BlaI or MecI, two gene repressors, and results in the induction of resistance. We report studies on the mechanism of binding of these gene repressors to the operator regions by fluorescence anisotropy. Within the range of in vivo concentrations for BlaI and MecI, these proteins interact with their regulatory elements in a reversible manner, as both a monomer and a dimer.
Palabras clave:
Methicillin-Resistant Staphylococcus Aureus
,
Blai
,
Meci
,
Regulation
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Articulos(IBR)
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Citación
Blázquez, Blas; Llarrull, Leticia Irene; Luque Ortega, Juan R.; Alfonso, Carlos; Boggess, Bill; et al.; Regulation of the Expression of the β-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA); American Chemical Society; Biochemistry; 53; 10; 2-2014; 1548-1550
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