Artículo
Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development
Abruzzese, Giselle Adriana
; Silva, Aimé Florencia
; Velazquez, Mariela Edith
; Ferrer, María José
; Motta, Alicia Beatriz
Fecha de publicación:
09/2022
Editorial:
John Wiley & Sons
Revista:
WIREs Mechanisms of Disease
e-ISSN:
2692-9368
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders affecting women of reproductive age. Its etiology remains unclear. It is suggested that environmental factors, and particularly the intrauterine environment, play key roles in PCOS development. Besides the role of androgens in PCOS pathogenesis, exposure to endocrine disruptors, as is Bisphenol A, could also contribute to its development. Although PCOS is considered one of the leading causes of ovarian infertility, many PCOS patients can get pregnant. Some of them by natural conception and others by assisted reproductive technique treatments. As hyperandrogenism (one of PCOS main features) affects ovarian and uterine functions, PCOS women, despite reaching pregnancy, could present high-risk pregnancies, including implantation failure, an increased risk of gestational diabetes, preeclampsia, and preterm birth. Moreover, hyperandrogenism may also be maintained in these women during pregnancy. Therefore, as an altered uterine milieu, including hormonal imbalance, could affect the developing organisms, monitoring these patients throughout pregnancy and their offspring development is highly relevant. The present review focuses on the impact of androgenism and PCOS on fertility issues and pregnancy-related outcomes and offspring development. The evidence suggests that the increased risk of pregnancy complications and adverse offspring outcomes of PCOS women would be due to the factors involved in the syndrome pathogenesis and the related co-morbidities. A better understanding of the involved mechanisms is still needed and could contribute to a better management of these women and their offspring. This article is categorized under: Reproductive System Diseases > Molecular and Cellular Physiology Reproductive System Diseases > Environmental Factors.
Palabras clave:
ANDROGENS
,
FERTILITY ISSUES
,
POLYCYSTIC OVARY SYNDROME
,
PREGNANCY
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Abruzzese, Giselle Adriana; Silva, Aimé Florencia; Velazquez, Mariela Edith; Ferrer, María José; Motta, Alicia Beatriz; Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development; John Wiley & Sons; WIREs Mechanisms of Disease; 14; 5; 9-2022; 1-29
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