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dc.contributor.author
Roulé, Thomas
dc.contributor.author
Christ, Aurelie
dc.contributor.author
Hussain, Nosheen
dc.contributor.author
Huang, Ying
dc.contributor.author
Hartmann, Caroline
dc.contributor.author
Benhamed, Moussa
dc.contributor.author
Gutierrez Marcos, Jose
dc.contributor.author
Ariel, Federico Damian
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dc.contributor.author
Crespi, Martin
dc.contributor.author
Blein, Thomas
dc.date.available
2023-10-02T12:56:59Z
dc.date.issued
2022-05
dc.identifier.citation
Roulé, Thomas; Christ, Aurelie; Hussain, Nosheen; Huang, Ying; Hartmann, Caroline; et al.; The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA; Oxford University Press; Molecular Plant; 15; 5; 5-2022; 840-856
dc.identifier.issn
1674-2052
dc.identifier.uri
http://hdl.handle.net/11336/213740
dc.description.abstract
Clustered organization of biosynthetic non-homologous genes is emerging as a characteristic feature of plant genomes. The co-regulation of clustered genes seems to largely depend on epigenetic reprogramming and three-dimensional chromatin conformation. In this study, we identified the long non-coding RNA (lncRNA) MARneral Silencing (MARS), localized inside the Arabidopsis marneral cluster, which controls the local epigenetic activation of its surrounding region in response to abscisic acid (ABA). MARS modulates the POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) component LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binding throughout the cluster in a dose-dependent manner, determining H3K27me3 deposition and chromatin condensation. In response to ABA, MARS decoys LHP1 away from the cluster and promotes the formation of a chromatin loop bringing together the MARNERAL SYNTHASE 1 (MRN1) locus and a distal ABA-responsive enhancer. The enrichment of co-regulated lncRNAs in clustered metabolic genes in Arabidopsis suggests that the acquisition of novel non-coding transcriptional units may constitute an additional regulatory layer driving the evolution of biosynthetic pathways.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ABA
dc.subject
CHROMATIN CONFORMATION
dc.subject
CLUSTER
dc.subject
ENHANCER
dc.subject
EPIGENETICS
dc.subject
LHP1
dc.subject
LNCRNA
dc.subject
MARNERAL
dc.subject
SEED GERMINATION
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T20:59:27Z
dc.journal.volume
15
dc.journal.number
5
dc.journal.pagination
840-856
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Roulé, Thomas. Universite Paris-Saclay;
dc.description.fil
Fil: Christ, Aurelie. Universite Paris-Saclay;
dc.description.fil
Fil: Hussain, Nosheen. University of Warwick; Reino Unido
dc.description.fil
Fil: Huang, Ying. Universite Paris-Saclay;
dc.description.fil
Fil: Hartmann, Caroline. Universite Paris-Saclay;
dc.description.fil
Fil: Benhamed, Moussa. Universite Paris-Saclay;
dc.description.fil
Fil: Gutierrez Marcos, Jose. University of Warwick; Reino Unido
dc.description.fil
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Crespi, Martin. Universite Paris-Saclay;
dc.description.fil
Fil: Blein, Thomas. Universite Paris-Saclay;
dc.journal.title
Molecular Plant
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molp.2022.02.007
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