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dc.contributor.author
Ogonowski, Natalia Soledad
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dc.contributor.author
Salcidua, Stefanny
dc.contributor.author
Leon, Tomas
dc.contributor.author
Chamorro Veloso, Nayaret
dc.contributor.author
Valls, Cristian
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Avalos, Constanza
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Bisquertt, Alejandro
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Rentería, Miguel E.
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Orellana, Paulina
dc.contributor.author
Duran Aniotz, Claudia
dc.date.available
2023-09-28T18:19:54Z
dc.date.issued
2022-01
dc.identifier.citation
Ogonowski, Natalia Soledad; Salcidua, Stefanny; Leon, Tomas; Chamorro Veloso, Nayaret; Valls, Cristian; et al.; Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 13; 1-2022; 1-22
dc.identifier.uri
http://hdl.handle.net/11336/213496
dc.description.abstract
The rate of progression from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD) is estimated at >10% per year, reaching up to 80–90% after 6 years. MCI is considered an indicator of early-stage AD. In this context, the diagnostic screening of MCI is crucial for detecting individuals at high risk of AD before they progress and manifest further severe symptoms. Typically, MCI has been determined using neuropsychological assessment tools such as the Montreal Cognitive Assessment (MoCA) or Mini-Mental Status Examination (MMSE). Unfortunately, other diagnostic methods are not available or are unable to identify MCI in its early stages. Therefore, identifying new biomarkers for MCI diagnosis and prognosis is a significant challenge. In this framework, miRNAs in serum, plasma, and other body fluids have emerged as a promising source of biomarkers for MCI and AD-related cognitive impairments. Interestingly, miRNAs can regulate several signaling pathways via multiple and diverse targets in response to pathophysiological stimuli. This systematic review aims to describe the current state of the art regarding AD-related target genes modulated by differentially expressed miRNAs in peripheral fluids samples in MCI subjects to identify potential miRNA biomarkers in the early stages of AD. We found 30 articles that described five miRNA expression profiles from peripheral fluid in MCI subjects, showing possible candidates for miRNA biomarkers that may be followed up as fluid biomarkers or therapeutic targets of early-stage AD. However, additional research is needed to validate these miRNAs and characterize the precise neuropathological mechanisms.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media S.A.
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BIOMARKERS
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DIAGNOSIS
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FLUID BIOMARKERS
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MICRORNA
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MILD COGNITIVE IMPAIRMENT
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SYSTEMATIC REVIEW
dc.subject.classification
Neurología Clínica
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-08-02T18:00:17Z
dc.identifier.eissn
1663-4365
dc.journal.volume
13
dc.journal.pagination
1-22
dc.journal.pais
Suiza
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dc.journal.ciudad
Lausana
dc.description.fil
Fil: Ogonowski, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Adolfo Ibañez; Chile
dc.description.fil
Fil: Salcidua, Stefanny. Universidad Adolfo Ibañez; Chile
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Fil: Leon, Tomas. Universidad de Chile; Chile. Trinity College; Irlanda
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Fil: Chamorro Veloso, Nayaret. Neurognos Spa; Chile
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Fil: Valls, Cristian. Neurognos Spa; Chile
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Fil: Avalos, Constanza. Universidad Adolfo Ibañez; Chile
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Fil: Bisquertt, Alejandro. Neurognos Spa; Chile
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Fil: Rentería, Miguel E.. Berghofer Medical Research Institute; Australia
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Fil: Orellana, Paulina. Universidad Adolfo Ibañez; Chile
dc.description.fil
Fil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; Chile
dc.journal.title
Frontiers in Aging Neuroscience
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnagi.2021.807764/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnagi.2021.807764
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