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Artículo

SARS-CoV-2-Specific IgG and IgA response in maternal blood and breastmilk of vaccinated naïve and convalescent lactating participants

Longueira, Yesica SoledadIcon ; Ojeda, Diego SebastianIcon ; Antivero Battistelli, Rocío B.; Sanchez, Lautaro; Oviedo Rouco, SantiagoIcon ; Albano, Daniel Rodolfo; Guevara, Eleonora; Valls, Vanesa; Pando, María de los ÁngelesIcon ; Gamarnik, Andrea VanesaIcon
Fecha de publicación: 10/2022
Editorial: Frontiers Media
Revista: Frontiers in Immunology
e-ISSN: 1664-3224
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Enfermedades Infecciosas

Resumen

Background: Recent studies have shown the presence of SARS-CoV-2-specific antibodies in the milk of breastfeeding mothers vaccinated with mRNA and convalescent. However, limited information is available in lactating women receiving other vaccine platforms used in developing countries, such as the inactivated SARS-CoV-2 vaccine BBIBP-CorV (Sinopharm) and the non-replicating adenovirus vaccines Sputnik V (Gamaleya Institute) and ChAdOx1-S (Oxford AstraZeneca). Methods: Here, we evaluated anti-SARS-CoV-2 IgG and IgA levels in both serum and milk samples using a longitudinal and a cross-sectional cohort of 208 breastfeeding vaccinated women from Argentina with or without previous SARS-CoV-2 infection. Results: The analysis showed that IgA levels remain constant in serum and milk of breastfeeding mothers between the first and second doses of vector-based vaccines (Sputnik V and ChAdOx1-S). After the second dose, anti-spike IgA was found positive in 100% of the serum samples and in 66% of breastmilk samples. In addition, no significant differences in milk IgA levels were observed in participants receiving BBIBP-CorV, Sputnik V or ChAdOx1-S. IgG levels in milk increased after the second dose of vector-based vaccines. Paired longitudinal samples taken at 45 and 120 days after the second dose showed a decrease in milk IgG levels over time. Study of IgA levels in serum and milk of vaccinated naïve of infection and vaccinated-convalescent breastfeeding participants showed significantly higher levels in vaccinated-convalescent than in participants without previous infection. Conclusion: This study is relevant to understand the protection against SARS-CoV-2 by passive immunity in newborns and children who are not yet eligible to receive vaccination.
Palabras clave: BBIBP-CORV , BREASTMILK , CHADOX1-S , COVID-19 VACCINE , IMMUNE RESPONSE , SARS-COV-2 , SPUTNIK V
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/213493
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.909995/full
DOI: https://doi.org/10.3389/fimmu.2022.909995
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Citación
Longueira, Yesica Soledad; Ojeda, Diego Sebastian; Antivero Battistelli, Rocío B.; Sanchez, Lautaro; Oviedo Rouco, Santiago; et al.; SARS-CoV-2-Specific IgG and IgA response in maternal blood and breastmilk of vaccinated naïve and convalescent lactating participants; Frontiers Media; Frontiers in Immunology; 13; 10-2022; 1-10
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