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dc.contributor.author
Glavac, Damjan
dc.contributor.author
Mladinic, Miranda
dc.contributor.author
Ban, Jelena
dc.contributor.author
Mazzone, Graciela Luján
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dc.contributor.author
Sámano, Cynthia
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Tomljanovic, Ivana
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Jezernik, Gregor
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Ravnik-Glavac, Metka
dc.date.available
2023-09-27T10:25:51Z
dc.date.issued
2022-09
dc.identifier.citation
Glavac, Damjan; Mladinic, Miranda; Ban, Jelena; Mazzone, Graciela Luján; Sámano, Cynthia; et al.; The Potential Connection between Molecular Changes and Biomarkers Related to ALS and the Development and Regeneration of CNS; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 19; 9-2022; 1-18
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/213170
dc.description.abstract
Neurodegenerative diseases are one of the greatest medical burdens of the modern age, being mostly incurable and with limited prognostic and diagnostic tools. Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by the loss of motoneurons, with a complex etiology, combining genetic, epigenetic, and environmental causes. The neuroprotective therapeutic approaches are very limited, while the diagnostics rely on clinical examination and the exclusion of other diseases. The recent advancement in the discovery of molecular pathways and gene mutations involved in ALS has deepened the understanding of the disease pathology and opened the possibility for new treatments and diagnostic procedures. Recently, 15 risk loci with distinct genetic architectures and neuron-specific biology were identified as linked to ALS through common and rare variant association analyses. Interestingly, the quantity of related proteins to these genes has been found to change during early postnatal development in mammalian spinal cord tissue (opossum Monodelphis domestica) at the particular time when neuroregeneration stops being possible. Here, we discuss the possibility that the ALS-related genes/proteins could be connected to neuroregeneration and development. Moreover, since the regulation of gene expression in developmental checkpoints is frequently regulated by non-coding RNAs, we propose that studying the changes in the composition and quantity of non-coding RNA molecules, both in ALS patients and in the developing central nervous (CNS) system of the opossum at the time when neuroregeneration ceases, could reveal potential biomarkers useful in ALS prognosis and diagnosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Molecular Diversity Preservation International
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ALS-RELATED GENES
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AMYOTROPHIC LATERAL SCLEROSIS
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CNS DEVELOPMENT
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NEUROREGENERATION
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NON-CODING RNAS
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PERIPHERAL BIOMARKERS
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The Potential Connection between Molecular Changes and Biomarkers Related to ALS and the Development and Regeneration of CNS
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T18:15:48Z
dc.journal.volume
23
dc.journal.number
19
dc.journal.pagination
1-18
dc.journal.pais
Suiza
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dc.description.fil
Fil: Glavac, Damjan. University of Ljubljana; Eslovenia
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Fil: Mladinic, Miranda. University of Rijeka; Croacia
dc.description.fil
Fil: Ban, Jelena. University of Rijeka; Croacia
dc.description.fil
Fil: Mazzone, Graciela Luján. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
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Fil: Sámano, Cynthia. Universidad Autónoma Metropolitana; México
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Fil: Tomljanovic, Ivana. University of Rijeka; Croacia
dc.description.fil
Fil: Jezernik, Gregor. University Oo Maribor; Eslovenia
dc.description.fil
Fil: Ravnik-Glavac, Metka. University of Ljubljana; Eslovenia
dc.journal.title
International Journal of Molecular Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/23/19/11360
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms231911360
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