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dc.contributor.author
Maier Gaelzer, Mariana
dc.contributor.author
Silva dos Santos, Mariana
dc.contributor.author
Paranhos Coelho, Bárbara
dc.contributor.author
de Quadros, Alice Hoffman
dc.contributor.author
Simão, Fabrício
dc.contributor.author
Usach, Vanina
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dc.contributor.author
Guma, Fátima Costa Rodrigues
dc.contributor.author
Setton, Clara Patricia
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dc.contributor.author
Lenz, Guido
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dc.contributor.author
Salbego, Christianne G.
dc.date.available
2017-07-25T21:53:50Z
dc.date.issued
2016-10
dc.identifier.citation
Maier Gaelzer, Mariana; Silva dos Santos, Mariana; Paranhos Coelho, Bárbara; de Quadros, Alice Hoffman; Simão, Fabrício; et al.; Hypoxic and reoxygenated microenvironment: stemness and differentiation state in glioblastoma; Springer; Molecular Neurobiology; 53; 8; 10-2016; 1-12
dc.identifier.issn
0893-7648
dc.identifier.uri
http://hdl.handle.net/11336/21315
dc.description.abstract
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment, and poor outcome. However, there is lack of studies relating type of cell death, status of Akt phosphorylation on Ser473, mitochondrial membrane potential, and morphological changes of tumor cells after hypoxia and reoxygenation. The rat glioma C6 cell line was exposed to oxygen deprivation (OD) in 5 % fetal bovine serum (FBS) or serum-free media followed by reoxygenation (RO). OD induced apoptosis on both 5 % FBS and serum-free groups. Overall, cells on serum-free media showed more profound morphological changes than cells on 5 % FBS. Moreover, our results suggest that OD combined with absence of serum provided a favorable environment for glioblastoma dedifferentiation to cancer stem cells, since nestin, and CD133 levels increased. Reoxygenation is present in hypoxic tumors through microvessel formation and cell migration to oxygenated areas. However, few studies approach these phenomena when analyzing hypoxia. We show that RO caused morphological alterations characteristic of cells undergoing a differentiation process due to increased GFAP. In the present study, we characterized an in vitro hypoxic microenvironment associated with GBM tumors, therefore contributing with new insights for the development of therapeutics for resistant glioblastoma.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cancer
dc.subject
Glioma
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Hypoxia
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Reoxygenation
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C6
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Cancer Stem Cell
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Hypoxic and reoxygenated microenvironment: stemness and differentiation state in glioblastoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-15T17:37:02Z
dc.identifier.eissn
1559-1182
dc.journal.volume
53
dc.journal.number
8
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Maier Gaelzer, Mariana. Universidade Federal Do Rio Grande Do Sul. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica; Brasil
dc.description.fil
Fil: Silva dos Santos, Mariana. Universidade Federal Do Rio Grande Do Sul. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica; Brasil
dc.description.fil
Fil: Paranhos Coelho, Bárbara. Universidade Federal Do Rio Grande Do Sul. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica; Brasil
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Fil: de Quadros, Alice Hoffman. Universidade Federal Do Rio Grande Do Sul. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica; Brasil
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Fil: Simão, Fabrício. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Usach, Vanina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Guma, Fátima Costa Rodrigues. Universidade Federal Do Rio Grande Do Sul. Instituto de Cs.basicas Da Saude. Dept.de Bioquímica; Brasil
dc.description.fil
Fil: Setton, Clara Patricia. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lenz, Guido. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Salbego, Christianne G.. Universidade Federal Do Rio Grande Do Sul. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica; Brasil
dc.journal.title
Molecular Neurobiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12035-016-0126-6
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12035-016-0126-6
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