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Artículo

Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina

Rodriguez, Pamela ElizabethIcon ; Silva, Andrea Paula; Miglietta, Esteban AlbertoIcon ; Rall, Pablo; Pascuale, Carla AntonelaIcon ; Ballejo, Christian Adrian; López Miranda, Lucía; Rios, Antonella SoledadIcon ; Ramis, Lila YaninaIcon ; Marro, Jimena; Poncet, Verónica; Mazzitelli, Bianca; Salvatori, MelinaIcon ; Ceballos, AnaIcon ; González López Ledesma, María MoraIcon ; Ojeda, Diego SebastianIcon ; Aguirre, María F.; Miragaya, Yanina; Gamarnik, Andrea VanesaIcon ; Rossi, Andrés HugoIcon
Fecha de publicación: 09/2022
Editorial: Frontiers Media
Revista: Frontiers in Immunology
ISSN: 1664-3224
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Matemática Pura

Resumen

The COVID-19 pandemic has particularly affected older adults residing in nursing homes, resulting in high rates of hospitalisation and death. Here, we evaluated the longitudinal humoral response and neutralising capacity in plasma samples of volunteers vaccinated with different platforms (Sputnik V, BBIBP-CorV, and AZD1222). A cohort of 851 participants, mean age 83 (60-103 years), from the province of Buenos Aires, Argentina were included. Sequential plasma samples were taken at different time points after vaccination. After completing the vaccination schedule, infection-naïve volunteers who received either Sputnik V or AZD1222 exhibited significantly higher specific anti-Spike IgG titers than those who received BBIBP-CorV. Strong correlation between anti-Spike IgG titers and neutralising activity levels was evidenced at all times studied (rho=0.7 a 0.9). Previous exposure to SARS-CoV-2 and age <80 years were both associated with higher specific antibody levels. No differences in neutralising capacity were observed for the infection-naïve participants in either gender or age group. Similar to anti-Spike IgG titers, neutralising capacity decreased 3 to 9-fold at 6 months after initial vaccination for all platforms. Neutralising capacity against Omicron was between 10-58 fold lower compared to ancestral B.1 for all vaccine platforms at 21 days post dose 2 and 180 days post dose 1. This work provides evidence about the humoral response and neutralising capacity elicited by vaccination of a vulnerable elderly population. This data could be useful for pandemic management in defining public health policies, highlighting the need to apply reinforcements after a complete vaccination schedule.
Palabras clave: AGING ADULTS , ANTI-SPIKE IGG , AZD1222 , BBIBP-CORV , NEUTRALISING ANTIBODIES , OMICRON , SARS-COV-2 , SPUTNIK-V , COVID-19
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/212931
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.992370/full
DOI: http://dx.doi.org/10.3389/fimmu.2022.992370
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Citación
Rodriguez, Pamela Elizabeth; Silva, Andrea Paula; Miglietta, Esteban Alberto; Rall, Pablo; Pascuale, Carla Antonela; et al.; Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina; Frontiers Media; Frontiers in Immunology; 13; 9-2022; 1-11
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