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dc.contributor.author
Galleano, Mónica Liliana
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dc.contributor.author
Bernatova, Iveta
dc.contributor.author
Puzserova, Angelika
dc.contributor.author
Balis, Peter
dc.contributor.author
Sestakova, Natalia
dc.contributor.author
Pechanova, Olga
dc.contributor.author
Fraga, César Guillermo
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dc.date.available
2017-07-25T18:35:47Z
dc.date.issued
2013-08
dc.identifier.citation
Galleano, Mónica Liliana; Bernatova, Iveta; Puzserova, Angelika; Balis, Peter; Sestakova, Natalia; et al.; (–)-Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO-mediated mechanism; Wiley; IUBMB Life; 65; 8; 8-2013; 710-715
dc.identifier.issn
1521-6543
dc.identifier.uri
http://hdl.handle.net/11336/21283
dc.description.abstract
Studies in humans have found consumption of certain flavanoid-containing foods to be associated with improvement in endothelial function and with reduction of blood pressure (BP). (-)-Epicatechin is a compound representative of the flavanols (a subfamily of flavonoids), abundant in cocoa seeds, which is preserved during the industrialization process to chocolate. The antihypertensive effect of dietary (-)-epicatechin was investigated on spontaneously hypertensive rats (SHR). Consumption of (-)-epicatechin-supplemented diet (3 g (-)-epicatechin/kg diet) decreased blood pressu re (BP) in SHR by 27 and 23 mm of Hg on days 2 and 6, respectively. On day 6,a 173% increase of nitric oxide (NO) synthase activity was observed in the aorta of EPI-SHR as compared to non-supplemented SHR (p<0.05). Responses to acetylcholine (ACh) were then examined in femoral arteries in the absence and the presence of with L-NAME, a non-selective NOS inhibitor, to assess the Ach-mediated relaxation ascribed to NO-dependent and independent mechanisms Acetylcholine-induced endothelium-dependent relaxation in the femoral artery was significantly higher in EPI-SHR than in SHR, with a predominance of the NO-dependent component of this relaxation. The endothelium-independent relaxation, assayed by using the NO donor sodium nitroprusside (SNP), resulted non significant different in the three experimental groups, demonstrating an unaffected function of vascular smooth muscle cells. These results give further support to the concept that (-)-epicatechin can modulate BP in hypertension by increasing NO levels in the vasculature.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Flavonoids
dc.subject
Hypertension
dc.subject
Nitric Oxide
dc.subject
Phytonutrients
dc.subject
Cocoa
dc.subject
Chocolate
dc.subject
Endothelial Dysfunction
dc.subject.classification
Nutrición, Dietética
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
(–)-Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO-mediated mechanism
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-25T14:59:06Z
dc.identifier.eissn
1521-6551
dc.journal.volume
65
dc.journal.number
8
dc.journal.pagination
710-715
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Galleano, Mónica Liliana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Bernatova, Iveta. Slovak Academy of Sciences; Eslovaquia
dc.description.fil
Fil: Puzserova, Angelika. Slovak Academy of Sciences; Eslovaquia
dc.description.fil
Fil: Balis, Peter. Slovak Academy of Sciences; Eslovaquia
dc.description.fil
Fil: Sestakova, Natalia. Slovak Academy of Sciences; Eslovaquia
dc.description.fil
Fil: Pechanova, Olga. Slovak Academy of Sciences; Eslovaquia
dc.description.fil
Fil: Fraga, César Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.journal.title
IUBMB Life
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/iub.1185
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/iub.1185/abstract
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