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dc.contributor.author
Galleano, Mónica Liliana  
dc.contributor.author
Bernatova, Iveta  
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Puzserova, Angelika  
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Balis, Peter  
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Sestakova, Natalia  
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Pechanova, Olga  
dc.contributor.author
Fraga, César Guillermo  
dc.date.available
2017-07-25T18:35:47Z  
dc.date.issued
2013-08  
dc.identifier.citation
Galleano, Mónica Liliana; Bernatova, Iveta; Puzserova, Angelika; Balis, Peter; Sestakova, Natalia; et al.; (–)-Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO-mediated mechanism; Wiley; IUBMB Life; 65; 8; 8-2013; 710-715  
dc.identifier.issn
1521-6543  
dc.identifier.uri
http://hdl.handle.net/11336/21283  
dc.description.abstract
Studies in humans have found consumption of certain flavanoid-containing foods to be associated with improvement in endothelial function and with reduction of blood pressure (BP). (-)-Epicatechin is a compound representative of the flavanols (a subfamily of flavonoids), abundant in cocoa seeds, which is preserved during the industrialization process to chocolate. The antihypertensive effect of dietary (-)-epicatechin was investigated on spontaneously hypertensive rats (SHR). Consumption of (-)-epicatechin-supplemented diet (3 g (-)-epicatechin/kg diet) decreased blood pressu re (BP) in SHR by 27 and 23 mm of Hg on days 2 and 6, respectively. On day 6,a 173% increase of nitric oxide (NO) synthase activity was observed in the aorta of EPI-SHR as compared to non-supplemented SHR (p<0.05). Responses to acetylcholine (ACh) were then examined in femoral arteries in the absence and the presence of with L-NAME, a non-selective NOS inhibitor, to assess the Ach-mediated relaxation ascribed to NO-dependent and independent mechanisms Acetylcholine-induced endothelium-dependent relaxation in the femoral artery was significantly higher in EPI-SHR than in SHR, with a predominance of the NO-dependent component of this relaxation. The endothelium-independent relaxation, assayed by using the NO donor sodium nitroprusside (SNP), resulted non significant different in the three experimental groups, demonstrating an unaffected function of vascular smooth muscle cells. These results give further support to the concept that (-)-epicatechin can modulate BP in hypertension by increasing NO levels in the vasculature.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Flavonoids  
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Hypertension  
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Nitric Oxide  
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Phytonutrients  
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Cocoa  
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Chocolate  
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Endothelial Dysfunction  
dc.subject.classification
Nutrición, Dietética  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
(–)-Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO-mediated mechanism  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-07-25T14:59:06Z  
dc.identifier.eissn
1521-6551  
dc.journal.volume
65  
dc.journal.number
8  
dc.journal.pagination
710-715  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Galleano, Mónica Liliana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.description.fil
Fil: Bernatova, Iveta. Slovak Academy of Sciences; Eslovaquia  
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Fil: Puzserova, Angelika. Slovak Academy of Sciences; Eslovaquia  
dc.description.fil
Fil: Balis, Peter. Slovak Academy of Sciences; Eslovaquia  
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Fil: Sestakova, Natalia. Slovak Academy of Sciences; Eslovaquia  
dc.description.fil
Fil: Pechanova, Olga. Slovak Academy of Sciences; Eslovaquia  
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Fil: Fraga, César Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.journal.title
IUBMB Life  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/iub.1185  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/iub.1185/abstract