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dc.contributor.author
Hurtado, Juan Pablo
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dc.contributor.author
Revale, Santiago
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dc.contributor.author
Matzkin, Luciano
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dc.date.available
2023-09-22T17:48:36Z
dc.date.issued
2022-12
dc.identifier.citation
Hurtado, Juan Pablo; Revale, Santiago; Matzkin, Luciano; Propagation of seminal toxins through binary expression gene drives could suppress populations; Nature; Scientific Reports; 12; 1; 12-2022; 1-13
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/212786
dc.description.abstract
Gene drives can be highly effective in controlling a target population by disrupting a female fertility gene. To spread across a population, these drives require that disrupted alleles be largely recessive so as not to impose too high of a fitness penalty. We argue that this restriction may be relaxed by using a double gene drive design to spread a split binary expression system. One drive carries a dominant lethal/toxic effector alone and the other a transactivator factor, without which the effector will not act. Only after the drives reach sufficiently high frequencies would individuals have the chance to inherit both system components and the effector be expressed. We explore through mathematical modeling the potential of this design to spread dominant lethal/toxic alleles and suppress populations. We show that this system could be implemented to spread engineered seminal proteins designed to kill females, making it highly effective against polyandrous populations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
gene drive
dc.subject
population suppression
dc.subject
genetic engineering
dc.subject
pests control
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Propagation of seminal toxins through binary expression gene drives could suppress populations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-30T10:47:14Z
dc.journal.volume
12
dc.journal.number
1
dc.journal.pagination
1-13
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Hurtado, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
dc.description.fil
Fil: Revale, Santiago. University of Oxford; Reino Unido
dc.description.fil
Fil: Matzkin, Luciano. University of Arizona; Estados Unidos
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-022-10327-4
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