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dc.contributor.author
Perello, Mario
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dc.contributor.author
Dickson, Suzanne L.
dc.contributor.author
Zigman, Jeffrey M.
dc.contributor.author
Leggio, Lorenzo
dc.date.available
2023-09-22T14:36:03Z
dc.date.issued
2022-12
dc.identifier.citation
Perello, Mario; Dickson, Suzanne L.; Zigman, Jeffrey M.; Leggio, Lorenzo; Toward a consensus nomenclature for ghrelin, its non-acylated form, liver expressed antimicrobial peptide 2 and growth hormone secretagogue receptor; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 35; 1; 12-2022; 1-6
dc.identifier.issn
0953-8194
dc.identifier.uri
http://hdl.handle.net/11336/212686
dc.description.abstract
The stomach-derived octanoylated peptide ghrelin was discovered in 1999 and recognized as an endogenous agonist of the growth hormone secretagogue receptor (GHSR). Subsequently, ghrelin has been shown to play key roles in controlling not only growth hormone secretion, but also a variety of other physiological functions including, but not limited to, food intake, reward-related behaviors, glucose homeostasis and gastrointestinal tract motility. Importantly, a non-acylated form of ghrelin, desacyl-ghrelin, can also be detected in biological samples. Desacyl-ghrelin, however, does not bind to GHSR at physiological levels, and its physiological role has remained less well-characterized than that of ghrelin. Ghrelin and desacyl-ghrelin are currently referred to in the literature using many different terms, highlighting the need for a consistent nomenclature. The variability of terms used to designate ghrelin can lead not only to confusion, but also to miscommunication, especially for those who are less familiar with the ghrelin literature. Thus, we conducted a survey among experts who have contributed to the ghrelin literature aiming to identify whether a consensus may be reached. Based on the results of this consensus, we propose using the terms “ghrelin” and “desacyl-ghrelin” to refer to the hormone itself and its non-acylated form, respectively. Based on the results of this consensus, we further propose using the terms “GHSR” for the receptor, and “LEAP2” for liver-expressed antimicrobial peptide 2, a recently recognized endogenous GHSR antagonist/inverse agonist.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
ACYL-GHRELIN
dc.subject
DESACYL GHRELIN
dc.subject
GHRELIN
dc.subject
UNACYLATED GHRELIN
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Toward a consensus nomenclature for ghrelin, its non-acylated form, liver expressed antimicrobial peptide 2 and growth hormone secretagogue receptor
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-04T13:36:49Z
dc.journal.volume
35
dc.journal.number
1
dc.journal.pagination
1-6
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.description.fil
Fil: Dickson, Suzanne L.. The Sahlgrenska Academy at the University of Gothenburg; Suecia
dc.description.fil
Fil: Zigman, Jeffrey M.. UT Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Leggio, Lorenzo. National Institutes of Health; Estados Unidos
dc.journal.title
Journal of Neuroendocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jne.13224
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/jne.13224
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