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dc.contributor.author
Barrantes, Francisco Jose
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dc.date.available
2023-09-21T14:42:00Z
dc.date.issued
2022-07
dc.identifier.citation
Barrantes, Francisco Jose; The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection; Pergamon-Elsevier Science Ltd; Progress in Lipid Research; 87; 7-2022; 1-13
dc.identifier.issn
0163-7827
dc.identifier.uri
http://hdl.handle.net/11336/212502
dc.description.abstract
The role of cholesterol in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronavirus-host cell interactions is currently being discussed in the context of two main scenarios: i) the presence of the neutral lipid in cholesterol-rich lipid domains involved in different steps of the viral infection and ii) the alteration of metabolic pathways by the virus over the course of infection. Cholesterol-enriched lipid domains have been reported to occur in the lipid envelope membrane of the virus, in the host-cell plasma membrane, as well as in endosomal and other intracellular membrane cellular compartments. These membrane subdomains, whose chemical and physical properties distinguish them from the bulk lipid bilayer, have been purported to participate in diverse phenomena, from virus-host cell fusion to intracellular trafficking and exit of the virions from the infected cell. SARS-CoV-2 recruits many key proteins that participate under physiological conditions in cholesterol and lipid metabolism in general. This review analyses the status of cholesterol and lipidome proteins in SARS-CoV-2 infection and the new horizons they open for therapeutic intervention.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHOLESTEROL
dc.subject
CHOLESTEROL METABOLISM
dc.subject
CHOLESTEROL-RICH LIPID DOMAINS
dc.subject
COVID-19 COMORBIDITIES
dc.subject
NEW THERAPEUTIC STRATEGIES FOR COVID-19
dc.subject
SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2)
dc.subject
STATINS
dc.subject
VIRUS INFECTION
dc.subject
COVID-19
dc.subject.classification
Patología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-10T11:12:08Z
dc.journal.volume
87
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
Progress in Lipid Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0163782722000212
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.plipres.2022.101166
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